Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,805 questions · 2,912 findings · 307 reviews · Headline outcomes only

No studies found 706 · 24.2%GRADE not reported 133 · 4.6%Very low 786 · 27%Low 696 · 23.9%Moderate 474 · 16.3%High 117 · 4%

Standard treatment plus systemic corticosteroids vs usual care

Preservation of visual acuity · patients age 10 years and older with periorbital or orbital cellulitis

It is very uncertain whether standard treatment plus systemic corticosteroids changes preservation of visual acuity compared with standard treatment alone (very low certainty).

1 finding from 1 review

Standard treatment plus systemic corticosteroids vs usual care

Severity of pain on day 3 · patients age 10 years and older with periorbital or orbital cellulitis

It is very uncertain whether standard treatment plus systemic corticosteroids changes severity of pain on day 3 compared with standard treatment alone (very low certainty).

1 finding from 1 review

Standard treatment plus systemic corticosteroids vs usual care

Duration of time requiring intravenous antibiotics · patients age 10 years and older with periorbital or orbital cellulitis

It is very uncertain whether standard treatment plus systemic corticosteroids changes duration of time requiring intravenous antibiotics compared with standard treatment alone (very low certainty).

1 finding from 1 review

Standard treatment plus systemic corticosteroids vs usual care

Surgical intervention · patients age 10 years and older with periorbital or orbital cellulitis

It is very uncertain whether standard treatment plus systemic corticosteroids changes need for surgical intervention compared with standard treatment alone (very low certainty).

1 finding from 1 review

Standard treatment plus systemic corticosteroids vs usual care

Adverse effects: exposure keratopathy · patients age 10 years and older with periorbital or orbital cellulitis

It is very uncertain whether standard treatment plus systemic corticosteroids changes adverse effects: exposure keratopathy compared with standard treatment alone (very low certainty).

1 finding from 1 review

Comparison 1: Individual CBT‐based psychotherapy vs TAU or another comparator

Repetition of SH at post‐intervention · self‐harm in children and adolescents (up to 18 years or age)

Comparison 1: Individual CBT‐based psychotherapy showed no clear difference in repetition of SH by post‐intervention compared with TAU or other comparator (low certainty).

1 finding from 1 review

Family therapy vs placebo

Repetition of SH at post‐intervention · self‐harm in children and adolescents (up to 18 years or age)

Comparison 7: Family therapy showed no clear difference in repetition of SH at post‐intervention compared with placebo (moderate certainty).

1 finding from 1 review

Posterior reconstruction vs no posterior reconstruction

Urinary continence within 1 week after catheter removal MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

Posterior reconstruction showed no clear difference in urinary continence within 1 week after catheter removal MCID: 5%… compared with no posterior reconstruction (low certainty).

1 finding from 1 review

Posterior reconstruction vs no posterior reconstruction

Urinary continence 3 months after surgery MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

Posterior reconstruction showed no clear difference in urinary continence 3 months after surgery MCID: 5% absolute difference compared with no posterior reconstruction (low certainty).

1 finding from 1 review

Posterior reconstruction vs no posterior reconstruction

Serious adverse events · men (ages > 18 years) with clinically localized prostate cancer

Posterior reconstruction showed no clear difference in serious adverse events compared with no posterior reconstruction (moderate certainty).

1 finding from 1 review

Posterior reconstruction vs no posterior reconstruction

Urinary continence 6 months after surgery MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

Posterior reconstruction showed no clear difference in urinary continence 6 months after surgery MCID: 5% absolute difference compared with no posterior reconstruction (moderate certainty).

1 finding from 1 review