Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Intense pulsed light vs no treatment

Participant global assessment: satisfaction with treatment ‐ inframammary Questionnaire · participants with hidradenitis suppurativa

Intense pulsed light showed no clear difference in participant global assessment: satisfaction with treatment ‐… compared with no treatment (low certainty).

1 finding from 1 review

Adalimumab weekly vs placebo

Treatment discontinuation · participants with hidradenitis suppurativa

Adalimumab weekly showed no clear difference in frequency of treatment discontinuation compared with placebo (moderate certainty).

1 finding from 1 review

Staphage lysate vs placebo broth

Physician Global Assessment (Thongprasom score) · participants with hidradenitis suppurativa

Staphage lysate probably leads to higher physician global assessment compared with placebo broth (moderate certainty).

1 finding from 1 review

Adalimumab weekly vs placebo

Proportion of participants with infectious adverse effects · participants with hidradenitis suppurativa

Adalimumab weekly showed no clear difference in proportion of participants with infectious adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Adalimumab weekly vs placebo

Proportion with improvement in pain VAS · participants with hidradenitis suppurativa

Adalimumab weekly probably leads to higher proportion with improvement in pain VAS compared with placebo (moderate certainty).

1 finding from 1 review

Adalimumab every other week vs placebo

Frequency of serious adverse effects · participants with hidradenitis suppurativa

Adalimumab every other week showed no clear difference in frequency of serious adverse effects compared with placebo (high certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Incidence of herpes labialis after use of the preventative intervention · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in incidence of herpes labialis during use of the preventative… compared with placebo (moderate certainty).

1 finding from 1 review

Valaciclovir (short‐term) vs placebo

Incidence of herpes labialis after use of the preventative intervention · participants with recurrent herpes labialis

Valaciclovir (short‐term) showed no clear difference in incidence of HSL during use of the preventative intervention (by… compared with placebo (moderate certainty).

1 finding from 1 review

Valaciclovir (short‐term) vs placebo

Incidence of HSL during use of the preventative intervention (by culture) · participants with recurrent herpes labialis

Valaciclovir (short‐term) showed no clear difference in incidence of HSL during use of the preventative intervention (by… compared with placebo (moderate certainty).

1 finding from 1 review