Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,411 questions · 2,571 findings · 265 reviews

No studies found 543 · 21.1%GRADE not reported 169 · 6.6%Very low 676 · 26.3%Low 731 · 28.4%Moderate 399 · 15.5%High 53 · 2.1%

Strategies to increase use of antenatal corticosteroids vs usual care

Neonatal death (death within the first 28 days of life) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher neonatal death before 28 days (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Stillbirth · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher stillbirth (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Appropriate ACS treatment (women) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids may leads to higher appropriate ACS treatment (women) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Inappropriate ACS treatment (women) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids may leads to higher inappropriate ACS treatment (women) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Maternal infection or inflammation (at population level) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids may leads to higher maternal infection or inflammation (at population level) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies to increase use of antenatal corticosteroids vs usual care

Maternal death · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids showed no clear difference in maternal mortality (at population level) compared with routine (usual) care (low certainty).

1 finding from 1 review

Acupuncture vs usual care

Adverse events Self‐reported · patients with non‐specific chronic low back pain

Acupuncture showed no clear difference in adverse events Self‐reported compared with usual care (low certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Number of minor postoperative bleeding episodes · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Outcome not reported · People with Von Willebrand disease undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Major bleeding, requiring transfusion of packed red blood cells · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Change in haemoglobin level from baseline · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Bleeding duration · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Need for and dose of clotting factor concentrates · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Any postoperative complication except bleeding (e.g. wound infection) · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

The review found no eligible studies for this question.

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Number of postoperative bleeding episodes requiring intervention · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic… probably leads to lower number of postoperative bleeding episodes requiring intervention compared with placebo, no intervention or usual care (with or without placebo) (moderate certainty).

1 finding from 1 review