Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Adalimumab every other week vs placebo

Proportion with improvement in pain · participants with hidradenitis suppurativa

Adalimumab every other week showed no clear difference in proportion with improvement in pain compared with placebo (moderate certainty).

1 finding from 1 review

Infliximab vs placebo

At least 50% decrease in HS Severity Index · participants with hidradenitis suppurativa

Infliximab showed no clear difference in at least 50% decrease in HS Severity Index compared with placebo (moderate certainty).

1 finding from 1 review

Infliximab vs placebo

Physician Global Assessment (Thongprasom score) · participants with hidradenitis suppurativa

Infliximab probably leads to higher physician global assessment compared with placebo (moderate certainty).

1 finding from 1 review

Topical clindamycin vs placebo

Adverse effects (non‐serious) · participants with hidradenitis suppurativa

Topical clindamycin showed no clear difference in adverse effects (non‐serious) compared with placebo (moderate certainty).

1 finding from 1 review

Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyloestradiol and norgestrel

Number of participants reporting non‐serious adverse effects · participants with hidradenitis suppurativa

Ethinyloestradiol and cyproterone acetate probably leads to lower number of participants reporting non‐serious adverse effects compared with ethinyloestradiol and norgestrel (moderate certainty).

1 finding from 1 review

Gentamicin sponge vs primary closure

Adverse effects ‐ complication rate at 1 week after surgery · participants with hidradenitis suppurativa

Gentamicin sponge showed no clear difference in adverse effects ‐ complication rate at 1 week after surgery compared with primary closure alone (moderate certainty).

1 finding from 1 review

Gentamicin sponge vs primary closure

Adverse effects ‐ complication rate at 3 months after surgery · participants with hidradenitis suppurativa

Gentamicin sponge showed no clear difference in adverse effects ‐ complication rate at 3 months after surgery compared with primary closure alone (moderate certainty).

1 finding from 1 review

Gentamicin sponge vs primary closure

Recurrence after surgery · participants with hidradenitis suppurativa

Gentamicin sponge showed no clear difference in recurrence rate at 3 months after surgery compared with primary closure alone (moderate certainty).

1 finding from 1 review

Intense pulsed light vs no treatment

Participant global assessment: satisfaction with treatment Questionnaire · participants with hidradenitis suppurativa

Intense pulsed light may leads to higher participant global assessment: satisfaction with treatment… compared with no treatment (low certainty).

1 finding from 1 review

Adalimumab weekly vs placebo

Frequency of serious adverse effects · participants with hidradenitis suppurativa

Adalimumab weekly showed no clear difference in frequency of serious adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Intense pulsed light vs no treatment

Participant global assessment: satisfaction with treatment ‐ axilla Questionnaire · participants with hidradenitis suppurativa

Intense pulsed light may leads to higher participant global assessment: satisfaction with treatment ‐ axilla… compared with no treatment (low certainty).

1 finding from 1 review

Intense pulsed light vs no treatment

Participant global assessment: satisfaction with treatment ‐ groin Questionnaire · participants with hidradenitis suppurativa

Intense pulsed light showed no clear difference in participant global assessment: satisfaction with treatment ‐ groin… compared with no treatment (low certainty).

1 finding from 1 review