What do systematic reviews say?

Toothbrushing (with or without antiseptics), as part of oral hygiene care vs No toothbrushing (with or without antiseptics)

The review found no eligible studies for this question.

• Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
  The outcome of cost was not reported by any study in this comparison.
  0 studies
  No studies found

Systemic (oral) betamethasone vs Topical triamcinolone acetonide paste

It is very uncertain whether systemic (oral) betamethasone changes pain resolution compared with topical triamcinolone acetonide paste (very low certainty).

• Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
  RR 1.04 [0.60, 1.80]
  1 study · 49 participants
  Very low

Ionisation (ionic air purifier) vs No ionisation / standard operatory

The review found no eligible studies for this question.

• Interventions to reduce contaminated aerosols produced during dental procedures for preventing infectious diseases 2020 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Doxycycline + SRP vs SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Horizontal mattress / fibrin sealant suturing vs Conventional (simple interrupted) suturing

The review found no eligible studies for this question.

• Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes

  up to 30 days
  no estimate extracted
  Studies not reported
  No studies found

Doxycycline + SRP vs Metronidazole + SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included studies have not reported this outcome
  Studies not reported
  No studies found

Azithromycin + SRP vs SRP

It is very uncertain whether azithromycin + SRP changes adverse events compared with SRP (very low certainty).

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  1 study reported diarrhoea, headache or dizziness, metallic taste, and general unwellness by 4 participants from the intervention group and 3 from the control group. In 1 study none of the participants reported any…
  2 studies · 110 participants
  Very low

Bone removal technique (chisel / piezoelectric / ultrasonic) vs Conventional mechanical caries removal (standard drill; handpiece with a bur)

The review found no eligible studies for this question.

• Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes

  >6 months
  no estimate extracted
  Studies not reported
  No studies found

Clobetasol propionate plus miconazole (adjunctive antifungal) vs Clobetasol propionate plus placebo

• Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
  Lodi 2007: no benefit of adjunctive miconazole for pain (low to very low certainty collectively)
  1 study
  GRADE not reported

Any method, procedure or policy to reduce contaminated aerosols in dental clinics vs Any other method, no treatment or combination of methods

The review found no eligible studies for this question.

• Interventions to reduce contaminated aerosols produced during dental procedures for preventing infectious diseases 2020 · Cochrane All outcomes
  Rate of infection of dental staff or patients: Not reported (row present in all Summary of findings tables)
  0 studies
  No studies found

Resin-based fissure sealant vs Fluoride varnish

Resin-based fissure sealant led to lower change in DMFT (decayed, missing and filled permanent teeth) increment compared with fluoride varnish; GRADE not reported.

• Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of children and… 2020 · Cochrane All outcomes

  2 years
  MD -0.08 [-0.14, -0.02]
  1 study · 542 participants
  GRADE not reported

Counter-stimulation or distraction vs Conventional treatment

It is very uncertain whether counter-stimulation or distraction changes self- or observational assessment of intraoperative… compared with conventional treatment (very low certainty).

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before or during LA
  RR 0.12 [0.04, 0.34]
  1 study · 134 participants
  Very low

Amoxicillin + metronidazole + SRP vs SRP

It is very uncertain whether amoxicillin + metronidazole + SRP changes adverse events compared with SRP (very low certainty).

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Most common adverse events were mild gastrointestinal disturbances, nausea and vomiting, metallic taste, and diarrhoea in the intervention group. Control group reported adverse events like hypothermia, mild…
  2 studies · 389 participants
  Very low

Clinical examination with risk-based recall vs Clinical examination with 6-month recall

Clinical examination with risk-based recall showed no clear difference in oral-health-related quality of life (OHIP-14) compared with clinical examination with 6-month recall (high certainty).

• Recall intervals for oral health in primary care patients 2020 · Cochrane All outcomes

  4 years
  MD -0.35 [-1.02, 0.32]
  1 study · 1551 participants
  High

Clinical examination with risk-based recall vs Clinical examination with 6-month recall

Clinical examination with risk-based recall showed no clear difference in dental caries: number of tooth surfaces with any caries (ICDAS 1-6) compared with clinical examination with 6-month recall (high certainty).

• Recall intervals for oral health in primary care patients 2020 · Cochrane All outcomes

  4 years
  MD 0.15 [-0.77, 1.08]
  1 study · 1478 participants
  High

Chlorhexidine vs Hydrogen peroxide

• Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes
  Chlorhexidine versus hydrogen peroxide (Dahiya 2012): no evidence of a difference in incidence of VAP; single study.
  1 study
  GRADE not reported

Hypnosis vs Conventional treatment

The review found no eligible studies for this question.

• Interventions for increasing acceptance of local anaesthetic in children and adolescents having dental treatment 2020 · Cochrane All outcomes

  Immediately before or during LA
  Completion of dental treatment: included studies did not report on this outcome
  Studies not reported
  No studies found

Combination system (Isolite) vs Rubber dam + HVE

It is very uncertain whether combination system (Isolite) changes reduction in level of contamination in aerosols (CFU) during water… compared with rubber dam + HVE (very low certainty).

• Interventions to reduce contaminated aerosols produced during dental procedures for preventing infectious diseases 2020 · Cochrane All outcomes
  MD -125.20 [-174.02, -76.38]
  1 study · 1 participants
  Very low

Radiograph and visual examination in combination vs Reference standard: histology

• Tests to detect and inform the diagnosis of root caries 2020 · Cochrane All outcomes
  Sensitivity 0.81 [0.54, 0.96]
  1 study
  Very low

Clindamycin + SRP vs Doxycycline + SRP

The review found no eligible studies for this question.

• Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes

  Long-term (≥ 1 year)
  Included study has not reported adverse events
  Studies not reported
  No studies found