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Evidence found and GRADE certainty

2,191 questions · 2,354 findings · 362 reviews

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No studies found 323 · 13.7%GRADE not reported 382 · 16.2%Very low 555 · 23.6%Low 597 · 25.4%Moderate 345 · 14.7%High 152 · 6.5%

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Metformin · people at increased risk for developing type 2 diabetes
2 findings from 1 review

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Acarbose · people at increased risk for developing type 2 diabetes
2 findings from 1 review

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Repaglinide · people at increased risk for developing type 2 diabetes
2 findings from 1 review

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Metformin Diagnostic criteria: 2 studies applied the WHO 1999 criteria for 'prediabetes' (FPG > 6.1 mmol/L and < 7.0 mmol/L and/or a 2‐h glucose < 11.1 mmol/L after a 75 g OGTT; Chen 2007a; Zeng 2013) · people at increased risk for developing type 2 diabetes

Summary of findings: pioglitazone monotherapy showed no clear difference in metformin Diagnostic criteria: 2 studies applied the WHO 1999… compared with another pharmacological glucose‐lowering monotherapy (low certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Acarbose Diagnostic criteria: 1 study applied the WHO 1999 criteria for prediabetes (FPG > 6.1 mmol/L and < 7.0 mmol/L and/or a 2‐h glucose < 11.1 mmol/L after a 75 g OGTT; Chen 2007a) · people at increased risk for developing type 2 diabetes
1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

Repaglinide Diagnostic criteria: 1 study applied the ADA 2010 criteria (FPG ≥ 5.6 mmol/L and < 6.9 mmol/L and 2‐h glucose ≥ 7.8 mmol/L or < 11.0 mmol/L after a 75 g OGTT; Zhang 2007) · people at increased risk for developing type 2 diabetes
1 finding from 1 review

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) · women with complete placenta praevia and intractable bleeding following caesarean section
1 finding from 1 review

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Number of women with total blood loss 1000 mL or more after randomisation · women with complete placenta praevia and intractable bleeding following caesarean section

The review found no eligible studies for this question.

1 finding from 1 review

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Blood transfusion (red cell or whole blood) · women with complete placenta praevia and intractable bleeding following caesarean section

It is very uncertain whether bakri balloon tamponade changes blood transfusion (red cell or whole blood) compared with haemostatic square suturing to the lower segment of the uterus… (very low certainty).

1 finding from 1 review

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Side effects of the intervention (e.g. trauma, necrosis) · women with complete placenta praevia and intractable bleeding following caesarean section
1 finding from 1 review

Higher JIA disease activity/severity (e.g., high JADAS/activity scores, polyarticular RF-negative subtype, active disease, anti-TNFalpha or cyclosporine medication) vs Lower JIA disease activity / inactive or milder JIA

Prevalence and severity of oral and TMJ diseases/conditions (periodontal status and dental caries) · Children and adolescents with juvenile idiopathic arthritis (JIA)

Some studies suggested greater JIA disease activity/severity (and certain medications) was associated with worse periodontal and caries outcomes, but small samples meant no solid conclusion could be drawn (ungraded).

1 finding from 1 review

Fluoride toothpaste vs Placebo (non-fluoride) toothpaste or fluoride toothpaste of a different concentration

Adverse effects of toothpaste · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1 finding from 1 review