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Evidence found and GRADE certainty

4,410 questions · 8,901 findings · 1,091 reviews

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No studies found 1,687 · 19%GRADE not reported 1,469 · 16.5%Very low 1,969 · 22.1%Low 2,060 · 23.1%Moderate 1,302 · 14.6%High 414 · 4.7%

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Facemask (with frame internal fixation) vs Frankel III functional appliance

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask (with frame internal fixation) showed no clear difference in ANB compared with frankel III functional appliance; GRADE not reported.

1 finding from 1 review

Facemask (RME) or modified facemask vs Other non-surgical orthodontic treatments (mini maxillary protractor, Pushing Splints, modified tandem, Reverse Forsus, reverse Twin Block, reverse chin cup, tongue appliance, Frankel III)

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

It is very uncertain whether facemask (RME) or modified facemask changes overjet compared with other non-surgical orthodontic treatments (mini maxillary… (very low certainty).

1 finding from 1 review

Bone-anchored intermaxillary traction (BAIMT) vs Removable mandibular retractor (RMR)

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Bone-anchored intermaxillary traction (BAIMT) led to higher ANB compared with removable mandibular retractor (RMR); GRADE not reported.

1 finding from 1 review

Hybrid Hyrax (RME) with miniscrews and Class III elastics vs Conventional Hyrax (RME) with miniscrews and Class III elastics

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Hybrid Hyrax (RME) with miniscrews and Class III elastics showed no clear difference in ANB compared with conventional Hyrax (RME) with miniscrews and Class III elastics; GRADE not reported.

1 finding from 1 review

Chin cup (600 g force) vs Chin cup (300 g force)

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Chin cup (600 g force) showed no clear difference in ANB compared with chin cup (300 g force); GRADE not reported.

1 finding from 1 review

Facemask vs no intervention

Perceived need for surgery in adulthood · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask may leads to higher perceived need for surgery in adulthood compared with untreated control (no treatment) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Planned hospital birth vs Planned home birth

Baby not breastfed · Pregnant women at low risk of complications

It is very uncertain whether summary of findings table ‐ Planned hospital birth changes baby not breastfed compared with planned home birth (very low certainty).

1 finding from 1 review

Serenoa repens vs placebo or no intervention

Urologic symptom scores · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Serenoa repens showed no clear difference in urologic symptom scoreMeasured by IPSS scores (range 0 to 35)Higher… compared with placebo or no intervention (high certainty).

1 finding from 1 review

Serenoa repens vs placebo or no intervention

QoL · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Serenoa repens showed no clear difference in quality of lifeMeasured by IPSS‐QoL score (range 0 to 6) compared with placebo or no intervention (high certainty).

1 finding from 1 review

Serenoa repens vs placebo or no intervention

Adverse eventsCumulative incidence · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Serenoa repens showed no clear difference in adverse eventsCumulative incidence compared with placebo or no intervention (moderate certainty).

1 finding from 1 review

Serenoa repens in combination with other phytotherapy vs placebo or no intervention

Urologic symptom scores · men with lower urinary tract symptoms secondary to benign prostatic obstruction

Serenoa repens in combination with other phytotherapy showed no clear difference in urologic symptom scoreMeasured by IPSS scores (range 0 to 35)Higher… compared with placebo or no intervention (low certainty).

1 finding from 1 review