Findings

What do systematic reviews say?

2,038 questions · 2,118 findings · 339 reviews

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No studies found 323 · 15.3%GRADE not reported 166 · 7.8%Very low 552 · 26.1%Low 592 · 28%Moderate 340 · 16.1%High 145 · 6.8%

Higher polyunsaturated fatty acid (PUFA) vs lower PUFA

Coronary heart disease mortality – CHD deaths · people with or without existing cardiovascular disease, men and women

Higher polyunsaturated fatty acid (PUFA) showed no clear difference in coronary heart disease mortality compared with lower PUFA (low certainty).

1 finding from 1 review

Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease 2018 · Cochrane Headline outcomes only
RR 0.91 [0.78, 1.06]
9 studies · 8810 participants
Low

Higher polyunsaturated fatty acid (PUFA) vs lower PUFA

Atrial fibrillation and arrhythmias · people with or without existing cardiovascular disease, men and women

It is very uncertain whether higher polyunsaturated fatty acid (PUFA) changes atrial fibrillation and arrhythmias compared with lower PUFA (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease 2018 · Cochrane Headline outcomes only
RR 0.87 [0.72, 1.06]
11 studies · 11692 participants
Very low

Higher polyunsaturated fatty acid (PUFA) vs lower PUFA

Weight (kg) · people with or without existing cardiovascular disease, men and women

1 finding from 1 review

Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease 2018 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 7100 participants
Moderate

Summary of findings: Higher bladder volume vs lower bladder volume

Mean GI symptom scores (during RT) · Men undergoing RT for prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Higher bladder volume vs lower bladder volume

Acute and late GI toxicity (grade 2+) · Men undergoing RT for prostate cancer

Summary of findings: Higher bladder volume showed no clear difference in acute and late GI toxicity (grade 2+) compared with lower bladder volume (low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 2.22 [0.62, 7.93]
1 study · 110 participants
Low

Summary of findings: Higher bladder volume vs lower bladder volume

Diarrhoea (grade 2+) · Men undergoing RT for prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Higher bladder volume vs lower bladder volume

QoL · Men undergoing RT for prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Keratinocyte growth factor (KGF), higher dose/regimen vs Keratinocyte growth factor (KGF), different (lower) dose/regimen

Oral mucositis (any severity) · Adults with cancer receiving treatment

1 finding from 1 review

Interventions for preventing oral mucositis in patients with cancer receiving treatment: cytokines and growth factors 2017 · Cochrane All outcomes
Some inconsistent evidence from which no conclusions can be drawn regarding different dosages of KGF (Analyses 2.1 to 2.8); no pooled estimate reported
Studies not reported
GRADE not reported

Summary of findings: punctal plugs in the upper vs lower puncta

Symptomatic improvement · adults with dry eye syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: punctal plugs in the upper vs lower puncta

Ocular surface staining · adults with dry eye syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: punctal plugs in the upper vs lower puncta

Aqueous tear production · adults with dry eye syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: punctal plugs in the upper vs lower puncta

Tear film stability · adults with dry eye syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: punctal plugs in the upper vs lower puncta

Artificial tear use · adults with dry eye syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: punctal plugs in the upper vs lower puncta

Adverse events · adults with dry eye syndrome

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Vaginal PGE2 vs intravenous (IV) oxytocin

Vaginal delivery not achieved within 24 hours · women with one previous lower segment caesarean section and requiring labour induction due to prolonged pregnancy or pre‐eclampsia,…

The review found no eligible studies for this question.

1 finding from 1 review

Methods of term labour induction for women with a previous caesarean section 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vaginal PGE2 vs intravenous (IV) oxytocin

Uterine hyperstimulation with fetal heart rate changes · women with one previous lower segment caesarean section and requiring labour induction due to prolonged pregnancy or pre‐eclampsia,…

The review found no eligible studies for this question.

1 finding from 1 review

Methods of term labour induction for women with a previous caesarean section 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vaginal isosorbide mononitrate vs Foley catheter

Vaginal delivery not achieved within 24 hours · pregnant women with 1 previous lower segment caesarean section at 37 weeks and beyond, with a BS of ≤ 6, intact membranes, reactive…

Vaginal isosorbide mononitrate may leads to higher vaginal delivery not achieved within 24 hours compared with foley catheter (low certainty).

1 finding from 1 review

Methods of term labour induction for women with a previous caesarean section 2017 · Cochrane Headline outcomes only
RR 2.63 [1.32, 5.21]
1 study · 80 participants
Low

Vaginal isosorbide mononitrate vs Foley catheter

Uterine hyperstimulation with fetal heart rate changes · pregnant women with 1 previous lower segment caesarean section at 37 weeks and beyond, with a BS of ≤ 6, intact membranes, reactive…

The review found no eligible studies for this question.

1 finding from 1 review

Methods of term labour induction for women with a previous caesarean section 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vaginal isosorbide mononitrate vs Foley catheter

Caesarean section · pregnant women with 1 previous lower segment caesarean section at 37 weeks and beyond, with a BS of ≤ 6, intact membranes, reactive…

It is very uncertain whether vaginal isosorbide mononitrate changes caesarean section compared with foley catheter (very low certainty).

1 finding from 1 review

Methods of term labour induction for women with a previous caesarean section 2017 · Cochrane Headline outcomes only
RR 1 [0.39, 2.59]
1 study · 80 participants
Very low

Vaginal isosorbide mononitrate vs Foley catheter

Serious neonatal morbidity or perinatal death · pregnant women with 1 previous lower segment caesarean section at 37 weeks and beyond, with a BS of ≤ 6, intact membranes, reactive…

The review found no eligible studies for this question.

1 finding from 1 review

Methods of term labour induction for women with a previous caesarean section 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found