Findings

What do systematic reviews say?

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

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No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Intervention not reported

DAB (low dose, 110 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1962 participants
Low

Intervention not reported

RVX (low dose, 2.5 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1403 participants
Low

Intervention not reported

DAB (low dose, 110 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1962 participants
Moderate

Intervention not reported

RVX (low dose, 2.5 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1403 participants
Low

Intervention not reported

DAB (low dose, 110 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1962 participants
Low

Intervention not reported

RVX (low dose, 2.5 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1399 participants
Low

Intervention not reported

DAB (low dose, 110 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1962 participants
Low

Intervention not reported

RVX (low dose, 2.5 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1399 participants
Low

Intervention not reported

RVX (low dose, 2.5 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1399 participants
Low

Intervention not reported

DAB (low dose, 110 mg) vs VKA · adults who underwent percutaneous coronary intervention and who have an indication for anticoagulation

1 finding from 1 review

Non‐vitamin K antagonist oral anticoagulants (NOACs) post‐percutaneous coronary intervention: a network meta‐analysis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1962 participants
Low

A dose of vitamin D 4000 IU/d or more vs 3999 IU/d or less alone or with any other nutrient

Low birthweight · women during pregnancy

A dose of vitamin D 4000 IU/d or more showed no clear difference in low birthweight compared with 3999 IU/d or less alone or with any other nutrient (low certainty).

1 finding from 1 review

Regimens of vitamin D supplementation for women during pregnancy 2019 · Cochrane Headline outcomes only
RR 0.92 [0.49, 1.7]
2 studies · 1099 participants
Low

Vitamin E vs placebo

Adverse effects/events ‐ extrapyramidal symptoms ‐ medium term Number of instances of extrapyramidal symptoms · patients with antipsychotic‐induced tardive dyskinesia

1 finding from 1 review

Vitamin E for antipsychotic‐induced tardive dyskinesia 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 104 participants
Very low

Epidural vs opioid

Maternal pain score measured during labour · women in labour

1 finding from 1 review

Epidural versus non‐epidural or no analgesia for pain management in labour 2018 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1133 participants
Low

Phototherapeutic keratectomy vs alcohol delamination

Painiv, SD units(lower scores indicate less pain) · people with recurrent corneal erosion syndrome without previous surgical intervention

1 finding from 1 review

Interventions for recurrent corneal erosions 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Low

Antibiotics vs placebo or usual care

Symptom score at 10 days. Measured on a 7‐point scale (0 to 6) ; lower score denotes fewer symptoms · acute asthma exacerbation

1 finding from 1 review

Antibiotics for exacerbations of asthma 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 2 participants
Moderate

Altered WBRT fractionation schedules vs WBRT control

Overall survival: higher‐dose WBRT vs control (3000 cGy/10 daily fractions)No. of participants: 846(4 RCTs) · patients with newly diagnosed multiple brain metastases

Altered WBRT fractionation schedules probably leads to higher overall survival: lower‐dose WBRT vs control WBRT (3000 cGy/10 daily… compared with WBRT control (moderate certainty).

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
HR 1.21 [1.04, 1.4]
Studies not reported
Moderate

Altered WBRT fractionation schedules vs WBRT control: neurological function improvement

Neurological function improvement: lower‐dose WBRT vs control dose WBRT (3000 cGy/10 fractions)No. of participants: 1612(5 RCTs) · patients with newly diagnosed multiple brain metastases

Altered WBRT fractionation schedules probably leads to higher neurological function improvement: lower‐dose WBRT vs control dose… compared with WBRT control: neurological function improvement (moderate certainty).

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
OR 1.74 [1.06, 2.84]
Studies not reported
Moderate

Intervention not reported

Pain: 50% reduction in headache frequency Post‐treatment Lower scores = fewer headaches · Children and adolescents with chronic pain

It is very uncertain whether the intervention changes pain: 50% reduction in headache frequency Post‐treatment Lower… (very low certainty).

1 finding from 1 review

Psychological therapies for the management of chronic and recurrent pain in children and adolescents 2018 · Cochrane Headline outcomes only
RR 2.35 [1.67, 3.3]
15 studies · 644 participants
Very low

Intervention not reported

Disability Post‐treatment Lower scores = lower reported disability · Children and adolescents with chronic pain

1 finding from 1 review

Psychological therapies for the management of chronic and recurrent pain in children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
14 studies · 1226 participants
Low

Intervention not reported

Anxiety Post‐treatment Lower scores = lower reported anxiety · Children and adolescents with chronic pain

1 finding from 1 review

Psychological therapies for the management of chronic and recurrent pain in children and adolescents 2018 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 883 participants
Low