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Evidence found and GRADE certainty

1,655 questions · 1,751 findings · 147 reviews · Pain, Palliative and Supportive Care

No studies found 361 · 20.6%GRADE not reported 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%

Tramadol vs placebo

Additional analgesia required (escape analgesia) · children undergoing surgery

Tramadol may leads to lower number of patients requiring rescue analgesia (PACU) compared with placebo (low certainty).

1 finding from 1 review

Tramadol vs pethidine

Additional analgesia required (escape analgesia) · children undergoing surgery

It is very uncertain whether tramadol changes number of patients requiring rescue analgesia (PACU) compared with pethidine (very low certainty).

1 finding from 1 review

Tramadol vs pethidine

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

Tramadol showed no clear difference in number of patients with moderate to severe pain (PACU) compared with pethidine (low certainty).

1 finding from 1 review

Tramadol vs pethidine

Number of patients with PONV (PACU) · children undergoing surgery

Tramadol showed no clear difference in number of patients with PONV (PACU) compared with pethidine (low certainty).

1 finding from 1 review

Tramadol vs fentanyl

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol vs placebo

Number of patients with PONV (PACU) · children undergoing surgery

Tramadol showed no clear difference in number of patients with PONV (PACU) compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol vs placebo

Number of patients with postoperative nausea and vomiting (24 hours postoperatively) · children undergoing surgery

Tramadol showed no clear difference in number of patients with PONV (24 hours postoperatively) compared with placebo (moderate certainty).

1 finding from 1 review

Tramadol vs morphine

Additional analgesia required (escape analgesia) · children undergoing surgery

Tramadol showed no clear difference in number of patients requiring rescue analgesia (PACU) compared with morphine (low certainty).

2 findings from 1 review

Tramadol vs morphine

Proportion of participants with moderate to severe pain up to 6 hours after the procedure · children undergoing surgery

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol vs nalbuphine

Additional analgesia required (escape analgesia) · children undergoing surgery

It is very uncertain whether tramadol changes number of patients requiring rescue analgesia (24 hours… compared with nalbuphine (very low certainty).

1 finding from 1 review