Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,289 questions · 2,331 findings · 195 reviews · Pregnancy and Childbirth

No studies found 480 · 20.6%GRADE not reported 288 · 12.4%Very low 467 · 20%Low 630 · 27%Moderate 338 · 14.5%High 128 · 5.5%

Routine/revealed vs selective/concealed ultrasound

Detection of fetal abnormality before 24 weeks' gestation · Fetal ultrasound assessment before 24 weeks' gestation

Routine/revealed probably leads to higher detection of fetal abnormality before 24 weeks' gestation compared with selective/concealed ultrasound (moderate certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo or no intervention

Low birthweight · healthy pregnant women receiving calcium supplementation vs placebo or no treatment

Calcium supplementation showed no clear difference in low birthweight (< 2500 g) compared with placebo or no treatment (maternal outcomes) (moderate certainty).

1 finding from 1 review

Tranexamic acid vs placebo/no treatment

Blood loss > 400 mL or > 500 mL · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage

Tranexamic acid probably leads to lower blood loss > 400 mL or > 500 mL compared with placebo/no treatment (moderate certainty).

1 finding from 1 review

Tranexamic acid vs placebo/no treatment

Blood loss > 1000 mL · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage

Tranexamic acid probably leads to lower blood loss > 1000 mL compared with placebo/no treatment (moderate certainty).

1 finding from 1 review

Tranexamic acid vs placebo/no treatment

Use of additional medical interventions to control PPH · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage

Tranexamic acid probably leads to lower use of additional medical interventions to control PPH compared with placebo/no treatment (moderate certainty).

1 finding from 1 review