Intervention not reported
Incidence of microleakage: Er,Cr:YSGG vs traditional bur (whole marginal line)
1 finding from 1 review
Qualitative NR [NR, NR]
1 study
GRADE not reported
Safety of sealants and fluoride varnishes (adverse events) · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
Time taken to apply pit and fissure sealant or fluoride varnish · Children and adolescents (general population, aged under 20 years)
The review found no eligible studies for this question.
1 finding from 1 review
Progression of dentinal carious lesions into enamel or dentine · Children and adolescents (general population, aged under 20 years)
Resin-modified glass ionomer fissure sealant showed no clear difference in progression of dentinal carious lesions into enamel or dentine compared with fluoride varnish; GRADE not reported.
1 finding from 1 review
Caries incidence of first permanent molars (FPMs) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…
After excluding the high-risk-of-bias study (Bravo 1996), fluoride varnish and fissure sealant did not differ in caries incidence of FPMs and heterogeneity fell to 0% (RR 1.05, 95% CI 0.91 to 1.22; 5 RCTs; ungraded).
3 findings from 1 review
Caries incidence (proportion of enrolled children developing dentin caries, ICDAS 4-6) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…
Fluoride varnish and fissure sealant did not differ significantly in the proportion of children developing caries at 2 to 3 years (RR 1.12, 95% CI 0.60 to 2.09; 2 RCTs; ungraded).
1 finding from 1 review
Intervention not reported
Microleakage/infiltration index: Er,Cr:YSGG vs traditional bur
1 finding from 1 review
Qualitative NR [NR, NR]
1 study
GRADE not reported
Number of visits to the dentist for repair of sealant or fluoride varnish application · Children and adolescents (general population, aged under 20 years)
The review found no eligible studies for this question.
1 finding from 1 review
Progression of dentinal carious lesions into enamel or dentine · Children and adolescents (general population, aged under 20 years)
The review found no eligible studies for this question.
1 finding from 1 review
Caries incidence of occlusal surfaces of first permanent molars · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…
After excluding Bravo 1996, occlusal caries incidence slightly favored fluoride varnish but was not significant, with heterogeneity falling to 0% (RR 0.98, 95% CI 0.82 to 1.16; 3 RCTs; ungraded).
2 findings from 1 review
Time taken to apply pit and fissure sealant or fluoride varnish · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
Changes in decayed, missing and filled (DMF) figures at whole-mouth level · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
Increment of occlusal DMFS (decayed, missing, filled surfaces) of FPMs · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…
Fluoride varnish and fissure sealant did not differ significantly in occlusal DMFS increment of FPMs (MD 0.13, 95% CI -0.09 to 0.34; 3 RCTs; ungraded).
2 findings from 1 review
Change in DMF increment on occlusal surfaces of first permanent molars · Children and adolescents (general population, aged under 20 years)
Resin-modified glass ionomer fissure sealant plus oral health… showed no clear difference in change in DMF increment on occlusal surfaces of first permanent molars compared with fluoride varnish plus oral health education; GRADE not reported.
2 findings from 1 review
MD 0.07 [-0.03, 0.17]
1 study
GRADE not reported
MD 0.23 [0.02, 0.44]
1 study
GRADE not reported
Change in DMFT (decayed, missing and filled permanent teeth) increment · Children and adolescents (general population, aged under 20 years)
Resin-based fissure sealant led to lower change in DMFT (decayed, missing and filled permanent teeth) increment compared with fluoride varnish; GRADE not reported.
1 finding from 1 review
Number of visits to the dentist for repair of sealant or fluoride varnish application · Children and adolescents (general population, aged under 20 years)
Resin-based fissure sealant led to higher number of visits to the dentist for repair of sealant or fluoride… compared with fluoride varnish; GRADE not reported.
1 finding from 1 review
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
SoF2: No evidence of a difference between interventions in caries after 1, 2 and 3 years; 995 (3 studies); Very low. Studies were clinically different so not combined in meta-analyses; 1 study (Tagliaferro 2011)…
3 studies · 995 participants
Very low
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
It is very uncertain whether resin-based fissure sealant plus fluoride varnish changes dentine caries in permanent molars (yes/no) compared with fluoride varnish alone (very low certainty).
1 finding from 1 review
Change in DMFS (decayed, missing and filled permanent surfaces) increment · Children and adolescents (general population, aged under 20 years)
Resin-based fissure sealant led to lower change in DMFS (decayed, missing and filled permanent surfaces)… compared with fluoride varnish; GRADE not reported.
1 finding from 1 review
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
It is very uncertain whether resin-based fissure sealant changes dentine caries in permanent molars (yes/no) compared with fluoride varnish (very low certainty).
1 finding from 1 review