Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,805 questions · 2,912 findings · 307 reviews · Headline outcomes only

No studies found 706 · 24.2%GRADE not reported 133 · 4.6%Very low 786 · 27%Low 696 · 23.9%Moderate 474 · 16.3%High 117 · 4%

N‐acetylcysteine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder

N‐acetylcysteine showed no clear difference in efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (low certainty).

1 finding from 1 review

Ketamine vs midazolam

Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults (aged 18 years+) with depression in bipolar disorder

It is very uncertain whether ketamine changes efficacy: number of participants who respond to treatment ‐ at 24… compared with midazolam (very low certainty).

1 finding from 1 review

Ketamine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults with Major Depressive Disorder

It is very uncertain whether ketamine changes efficacy: number of participants who respond to treatment ‐ at 24… compared with placebo (very low certainty).

1 finding from 1 review