Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

309 questions · 321 findings · 28 reviews · Headline outcomes only

No studies found 45 · 14%GRADE not reported 21 · 6.5%Very low 91 · 28.3%Low 65 · 20.2%Moderate 82 · 25.5%High 17 · 5.3%

RISPERIDONE DEPOT vs ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE)

Adverse events: Any prolactin‐related ‐ medium term · patients with schizophrenia

RISPERIDONE DEPOT showed no clear difference in adverse events: Any prolactin‐related ‐ medium term compared with ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE) (moderate certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE)

Adverse events: Any glucose‐related ‐ medium/long term · patients with schizophrenia

RISPERIDONE DEPOT showed no clear difference in adverse events: Any glucose‐related ‐ medium/long term compared with ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE) (low certainty).

1 finding from 1 review

Pericyazine vs Typical antipsychotics

Global state: no improvement ‐ medium termAs defined in each study · patients with schizophrenia

It is very uncertain whether pericyazine changes global state ‐ not improved compared with typical antipsychotic (very low certainty).

1 finding from 1 review

Pericyazine vs atypical antipsychotics

Leaving the study early for specific reasons · patients with schizophrenia

It is very uncertain whether pericyazine changes leaving the study early for specific reasons compared with atypical antipsychotic (very low certainty).

1 finding from 1 review

Pericyazine vs Typical antipsychotics

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

It is very uncertain whether pericyazine changes adverse events ‐ for specific reasons ‐ Extrapyramidal side effect compared with typical antipsychotic (very low certainty).

1 finding from 1 review

Pericyazine vs Typical antipsychotics

Leaving the study early for specific reasons · patients with schizophrenia

It is very uncertain whether pericyazine changes leaving the study early for specific reasons compared with typical antipsychotic (very low certainty).

1 finding from 1 review

Pericyazine vs atypical antipsychotics

Global state: no improvement ‐ medium termAs defined in each study · patients with schizophrenia

It is very uncertain whether pericyazine changes global state ‐ not improved compared with atypical antipsychotic (very low certainty).

1 finding from 1 review

Pericyazine vs atypical antipsychotics

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

It is very uncertain whether pericyazine changes adverse Effects ‐ Extrapyramidal symptoms compared with atypical antipsychotic (very low certainty).

1 finding from 1 review