Findings

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Evidence found and GRADE certainty

154 questions · 243 findings · 7 reviews · Periodontology

No studies found 55 · 22.6%GRADE not reported 138 · 56.8%Very low 45 · 18.5%Low 4 · 1.6%Moderate 1 · 0.4%High 0 · 0%

Doxycycline + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

3 findings from 1 review

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with clarithromycin + SRP; GRADE not reported.

2 findings from 1 review

Amoxicillin + clavulanate + SRP vs Tetracycline + SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

Amoxicillin + clavulanate + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with tetracycline + SRP; GRADE not reported.

1 finding from 1 review

Metronidazole + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether metronidazole + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Metronidazole + SRP vs Amoxicillin + metronidazole + SRP

Probing pocket depth · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in probing pocket depth compared with amoxicillin + metronidazole + SRP; GRADE not reported.

2 findings from 1 review

Metronidazole + SRP vs SRP

Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with SRP; GRADE not reported.

3 findings from 1 review

Metronidazole + SRP vs Amoxicillin + metronidazole + SRP

Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with amoxicillin + metronidazole + SRP; GRADE not reported.

2 findings from 1 review

Moxifloxacin + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis

Moxifloxacin + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.

2 findings from 1 review