Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

181 questions · 198 findings · 16 reviews · Neonatal

No studies found 28 · 14.1%GRADE not reported 11 · 5.6%Very low 71 · 35.9%Low 71 · 35.9%Moderate 16 · 8.1%High 1 · 0.5%

HFNC vs continuous positive airway pressure (CPAP)

Treatment failure · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))

It is very uncertain whether summary of findings table ‐ High flow nasal cannula (HFNC) changes treatment failure compared with continuous positive airway pressure (CPAP) (very low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Duration of any form of respiratory support (any form of non‐invasive respiratory support with or without supplemental oxygen) · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))
1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Adverse events ‐ nasal trauma · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))

It is very uncertain whether summary of findings table ‐ High flow nasal cannula (HFNC) changes adverse events ‐ nasal trauma compared with continuous positive airway pressure (CPAP) (very low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Adverse events ‐ abdominal overdistention · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))

It is very uncertain whether summary of findings table ‐ High flow nasal cannula (HFNC) changes adverse events ‐ abdominal overdistention compared with continuous positive airway pressure (CPAP) (very low certainty).

1 finding from 1 review

HFNC vs low flow nasal cannula (LFNC)

Treatment failure · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))

Summary of findings table ‐ High flow nasal cannula (HFNC) may leads to lower treatment failure compared with low flow nasal cannula (LFNC) (low certainty).

1 finding from 1 review

Continuous glucose monitoring system vs intermittent modalities

All‐cause mortality during initial hospitalization ‐ not reported · infants at risk of hypoglycaemia or hyperglycaemia

It is very uncertain whether summary of findings table ‐ Continuous glucose monitoring (CGM) changes death during initial hospitalization (all‐cause mortality) compared with intermittent modalities (very low certainty).

1 finding from 1 review