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Evidence found and GRADE certainty

127 questions · 128 findings · 30 reviews · Pregnancy and Childbirth

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No studies found 31 · 24.2%GRADE not reported 11 · 8.6%Very low 17 · 13.3%Low 43 · 33.6%Moderate 19 · 14.8%High 7 · 5.5%

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Cleft palate (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate showed no clear difference in cleft palate (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).

1 finding from 1 review

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Congenital cardiovascular anomalies (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate showed no clear difference in congenital cardiovascular anomalies (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).

1 finding from 1 review

Supplementation with folate vs no intervention, placebo or other micronutrients without folate (neonatal outcomes)

Other congenital anomalies (All) · all women who become pregnant or were 12 or less weeks' pregnant at the time of the intervention

Supplementation with folate showed no clear difference in other congenital anomalies (All) compared with no intervention, placebo or other micronutrients without folate… (low certainty).

1 finding from 1 review