Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

628 questions · 651 findings · 39 reviews · Skin

No studies found 167 · 25.7%GRADE not reported 47 · 7.2%Very low 80 · 12.3%Low 139 · 21.4%Moderate 174 · 26.7%High 44 · 6.8%

Any systemic treatment vs placebo

Brodalumab · people with chronic plaque psoriasis

Any systemic treatment showed no clear difference in brodalumab compared with placebo (moderate certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Secukinumab · people with chronic plaque psoriasis

Any systemic treatment showed no clear difference in secukinumab compared with placebo (moderate certainty).

2 findings from 1 review

Topical vitamin D derivative vs placebo

Proportion of participants with adverse effects ‐ measured over 8 weeks · chronic palmoplantar pustulosis

Topical vitamin D derivative showed no clear difference in proportion of participants with adverse effects ‐ measured over 8… compared with placebo (moderate certainty).

1 finding from 1 review

Etretinate vs placebo or no treatment

Proportion of participants cleared or almost cleared ‐ · chronic palmoplantar pustulosis

It is very uncertain whether etretinate changes proportion of participants cleared or almost cleared in the short… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Etretinate vs placebo or no treatment

Proportion of participants without relapse in the long term ‐ not reported · chronic palmoplantar pustulosis

It is very uncertain whether etretinate changes proportion of participants without relapse in the long term (6 months) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Etretinate vs placebo or no treatment

Proportion of participants with adverse effects ‐ measured over 8 weeks · chronic palmoplantar pustulosis

It is very uncertain whether etretinate changes proportion of participants with adverse effects ‐ measured over 12… compared with placebo or no treatment (very low certainty).

1 finding from 1 review