Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

489 questions · 532 findings · 33 reviews · Headline outcomes only

No studies found 55 · 10.3%GRADE not reported 28 · 5.3%Very low 119 · 22.4%Low 167 · 31.4%Moderate 129 · 24.2%High 34 · 6.4%

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Toxicity · palliative participants with AC of the esophagus

It is very uncertain whether summary of findings table (subcomparison 5): chemotherapy or… changes toxicity compared with control intervention alone (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Overall survival · palliative participants with SCC of the esophagus

Summary of findings table (subcomparison 6): chemotherapy or… leads to lower overall survival compared with control intervention alone (high certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Progression‐free survival · palliative participants with SCC of the esophagus

It is very uncertain whether summary of findings table (subcomparison 6): chemotherapy or… changes progression‐free survival compared with control intervention alone (very low certainty).

1 finding from 1 review

Summary of findings table (subcomparison 5): chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention

Toxicity · palliative participants with SCC of the esophagus

It is very uncertain whether summary of findings table (subcomparison 6): chemotherapy or… changes toxicity compared with control intervention alone (very low certainty).

1 finding from 1 review

Transference‐Focused Psychotherapy (TFP) vs community treatment by experts (CTBE)

Suicidality ‐ CBT vs. TAUno. of participants with suicidal act (last 12 months) · patients with borderline personality disorder

Transference‐Focused Psychotherapy (TFP) showed no clear difference in suicidalityno. of participants with suicidal act (last 12 months) compared with community treatment by experts (CTBE) (moderate certainty).

1 finding from 1 review

Transference‐Focused Psychotherapy (TFP) vs community treatment by experts (CTBE)

Parasuicidality ‐ CBT vs. TAUno. of participants with self‐harming behaviour (last 12 months) · patients with borderline personality disorder

Transference‐Focused Psychotherapy (TFP) showed no clear difference in parasuicidalityno. of participants with self‐harming behaviour (last… compared with community treatment by experts (CTBE) (moderate certainty).

1 finding from 1 review

Psychotherapy as an adjunct to usual care vs usual care

Depressive symptoms · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care showed no clear difference in self‐reported depressive symptoms short term (up to 6 months) ‐ BDI… compared with usual care alone (moderate certainty).

8 findings from 1 review
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Psychotherapy as an adjunct to usual care vs usual care

Dropout · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care showed no clear difference in dropout medium term (7 to 12 months)* compared with usual care alone (moderate certainty).

2 findings from 1 review