Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

281 questions · 285 findings · 20 reviews · Skin

No studies found 42 · 14.7%GRADE not reported 88 · 30.9%Very low 22 · 7.7%Low 75 · 26.3%Moderate 47 · 16.5%High 11 · 3.9%

Pentoxifylline (oral 400 mg thrice daily) plus meglumine antimoniate (IMMA) (20 mg/ kg /day for 20 days) vs IMMA plus placebo

Complete cure, at least 3 months after the end of treatment · People with American cutaneous leishmaniasis

Pentoxifylline (oral 400 mg thrice daily) plus meglumine antimoniate… showed no clear difference in complete cure, at least 3 months after the end of treatment compared with IMMA plus placebo (moderate certainty).

1 finding from 1 review

Skin care intervention vs standard skin care or no skin care intervention

IgE‐mediated food allergy (oral food challenge) by 1 to 3 years · infants

Skin care intervention showed no clear difference in igE‐mediated food allergy (oral food challenge) by 1 to 3 years compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Any systemic treatment vs placebo

Oral Tyrosine kinase 2 (TYK2) inhibitor · people with chronic plaque psoriasis

Any systemic treatment may leads to higher oral tyrosine kinase 2 (TYK2) inhibitor compared with placebo (low certainty).

2 findings from 1 review

Clobetasol propionate cream vs prednisone

Disease control (healing of skin lesions) at day 21 · bullous pemphigoid

Clobetasol propionate cream probably leads to higher disease control (healing of skin lesions) at day 21 compared with oral prednisone (moderate certainty).

1 finding from 1 review

Clobetasol propionate cream vs prednisone

Adverse events: severe complications at day 21 · bullous pemphigoid

Clobetasol propionate cream may leads to lower adverse events: severe complications at day 21 compared with oral prednisone (low certainty).

1 finding from 1 review