Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,935 questions · 1,986 findings · 260 reviews · Headline outcomes only

No studies found 503 · 25.3%GRADE not reported 76 · 3.8%Very low 593 · 29.9%Low 509 · 25.6%Moderate 241 · 12.1%High 64 · 3.2%

Multi‐component intervention vs usual care or attention control

Falls · Older people living in the community

Multiple component interventions probably leads to lower rate of falls (falls per person years) compared with usual care or attention control (moderate certainty).

1 finding from 1 review

Multi‐component intervention vs usual care or attention control

Number of people sustaining recurrent falls (defined as two or more falls in a specified time period) · Older people living in the community

Multiple component interventions showed no clear difference in number of people sustaining recurrent falls (defined as two or more… compared with usual care or attention control (low certainty).

1 finding from 1 review

Multi‐component intervention vs usual care or attention control

Number of people who experience a fall that required hospital admission · Older people living in the community

It is very uncertain whether multiple component interventions changes number of people who experience a fall that required hospital… compared with usual care or attention control (very low certainty).

1 finding from 1 review

Multi‐component intervention vs usual care or attention control

Number of people who experience a fall that required medical attention · Older people living in the community

Multiple component interventions showed no clear difference in number of people who experience a fall that required medical attention compared with usual care or attention control (low certainty).

1 finding from 1 review

Multi‐component intervention vs exercise

Number of people who experience a fall that required hospital admission · Older people living in the community

It is very uncertain whether multiple component interventions changes number of people who experience a fall that require hospital admission compared with exercise (very low certainty).

1 finding from 1 review

Primary care physician alerting system and a patient‐directed intervention (education and reminder to see their primary care physician) vs usual care

Bone mineral density · General practitioners/family doctors involved in the management of patients with osteoporosis

Primary care physician alerting system and a patient‐directed… leads to higher bone Mineral Density 1 compared with standard care (high certainty).

1 finding from 1 review

Comparison 1: antibiotic alone or antibiotic with other newborn care interventions vs usual care

Neonatal mortality · neonates with sepsis

Comparison 1: antibiotic alone or antibiotic with other newborn care… showed no clear difference in neonatal mortality ‐ antibiotics alone compared with standard care (moderate certainty).

2 findings from 1 review

Provider‐ or system‐based interventions vs no intervention or another intervention

Posters in clinic displaying influenza vaccination rates to encourage doctors to compete plus postcards to participants compared to posters alone · people aged 60 years and older living in the community

Provider‐ or system‐based interventions showed no clear difference in posters in clinic displaying influenza vaccination rates to… compared with no intervention or another intervention (high certainty).

1 finding from 1 review

Multifactorial interventions vs exercise

Number of people who experienced one or more falls · Older people living in the community

It is very uncertain whether multifactorial interventions changes number of people sustaining one or more falls compared with exercise (very low certainty).

1 finding from 1 review