Combination leads to higher smoking cessation compared with single‐form nicotine replacement therapy (high certainty).
Combination showed no clear difference in overall serious adverse events compared with single‐form nicotine replacement therapy (low certainty).
It is very uncertain whether combination changes treatment withdrawals compared with single‐form nicotine replacement therapy (very low certainty).
It is very uncertain whether longer changes smoking cessation ‐ 16 weeks versus 8 weeks compared with shorter duration of combination nicotine replacement therapy (very low certainty).
Longer showed no clear difference in smoking cessation ‐ 6 weeks versus 2 weeks compared with shorter duration of combination nicotine replacement therapy (low certainty).
It is very uncertain whether longer changes overall SAEs ‐ 26 weeks versus 8 weeks compared with shorter duration of combination nicotine replacement therapy (very low certainty).
Early showed no clear difference in death at day 30Â compared with standard initiation of kidney replacement therapy (KRT) (low certainty).
Subgroup analyses: early showed no clear difference in death by AKI aetiology: non‐surgical causes compared with standard initiation of kidney replacement therapy (KRT) (moderate certainty).
Subgroup analyses: early showed no clear difference in death by AKI aetiology: surgical causes compared with standard initiation of kidney replacement therapy (KRT) (low certainty).
Subgroup analyses: early showed no clear difference in kidney recovery functionby KRT: continuous KRT compared with standard initiation of kidney replacement therapy (KRT) (moderate certainty).
Subgroup analyses: early showed no clear difference in kidney recovery functionby KRT: continuous and intermittent KRT compared with standard initiation of kidney replacement therapy (KRT) (moderate certainty).
Early showed no clear difference in death after 30 days compared with standard initiation of kidney replacement therapy (KRT) (moderate certainty).
Early showed no clear difference in death or non‐recovery of kidney function Time frame: day 90 compared with standard initiation of kidney replacement therapy (KRT) (low certainty).
Early showed no clear difference in recovery of kidney function Patients free from KRT according to ITT… compared with standard initiation of kidney replacement therapy (KRT) (low certainty).
Early leads to higher adverse events: hypophosphataemia compared with standard initiation of kidney replacement therapy (KRT) (high certainty).
Early leads to higher adverse events: hypotension compared with standard initiation of kidney replacement therapy (KRT) (high certainty).
Early leads to higher adverse events: cardiac‐rhythm disorder compared with standard initiation of kidney replacement therapy (KRT) (high certainty).
Early showed no clear difference in adverse events: infection compared with standard initiation of kidney replacement therapy (KRT) (high certainty).