Findings

What do systematic reviews say?

125 questions · 128 findings · 14 reviews · All outcomes

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No studies found 6 · 4.7%GRADE not reported 82 · 64.1%Very low 30 · 23.4%Low 8 · 6.3%Moderate 0 · 0%High 2 · 1.6%

Teriparatide 56.5 microg weekly in addition to standard care vs Teriparatide 20 microg daily in addition to standard care

Healing of MRONJ (remission) · People with established (manifest) MRONJ

It is very uncertain whether teriparatide 56.5 microg weekly in addition to standard care changes healing of MRONJ (remission) compared with teriparatide 20 microg daily in addition to standard care (very low certainty).

1 finding from 1 review

Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes
6 months
RR 0.60 [0.25, 1.44]
1 study · 12 participants
Very low

Subperiosteal prepared (SPP) wound closure after tooth extraction vs Epiperiosteal prepared (EPP) wound closure after tooth extraction

MRONJ after tooth extraction (incidence proportion) · People on antiresorptive treatment undergoing tooth extraction (at risk of MRONJ)

Subperiosteal prepared (SPP) wound closure after tooth extraction showed no clear difference in MRONJ after tooth extraction (incidence proportion) compared with epiperiosteal prepared (EPP) wound closure after tooth extraction (low certainty).

1 finding from 1 review

Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes
6 months
RR 0.09 [0.00, 1.56]
1 study · 132 participants
Low

Hyperbaric oxygen therapy (HBO) as an adjunct to conventional therapy vs conventional therapy

Quality of life · People with established (manifest) MRONJ

1 finding from 1 review

Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes
6 months
QoL measured with the Duke Health Profile; only within-group comparisons were provided; no score values, so a between-group analysis was not possible.
1 study
GRADE not reported

Dental extraction protocol with plasma rich in growth factors (PRGF) inserted into the postextraction alveolus vs Standard dental extraction protocol without PRGF

MRONJ (incidence proportion) · People with cancer treated with intravenous bisphosphonates undergoing dental extractions (at risk of MRONJ)

It is very uncertain whether dental extraction protocol with plasma rich in growth factors (PRGF)… changes MRONJ (incidence proportion) compared with standard dental extraction protocol without PRGF (very low certainty).

1 finding from 1 review

Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes
24 to 60 months
RR 0.08 [0.00, 1.51]
1 study · 176 participants
Very low

Dental examinations at three-month intervals and preventive treatments vs usual care

MRONJ (incidence rate: cases per patient-year) · Men with metastatic prostate cancer receiving intravenous zoledronic acid (at risk of MRONJ)

It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence rate: cases per patient-year) compared with standard care (very low certainty).

1 finding from 1 review

Interventions for managing medication‐related osteonecrosis of the jaw 2022 · Cochrane All outcomes
mean 28.8 months
rate ratio 0.18 [0.04, 0.74]
1 study · 253 participants
Very low