Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

748 questions · 782 findings · 58 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 164 · 21%GRADE not reported 26 · 3.3%Very low 151 · 19.3%Low 222 · 28.4%Moderate 158 · 20.2%High 61 · 7.8%

Hypofractionated radiotherapy vs daily conventionally fractionated radiotherapy

Overall survival for subgroup age 60 years and older glioblastoma · high‐grade glioma

Hypofractionated radiotherapy showed no clear difference in overall survival for subgroup aged ≥ 60 years glioblastoma compared with daily conventionally fractionated radiotherapy (high certainty).

1 finding from 1 review

Anti‐EGFR antibody plus chemotherapy vs chemotherapy alone

Grade 3 to 4 diarrhoea · treatment of relapsed epithelial ovarian cancer

It is very uncertain whether anti‐EGFR antibody plus chemotherapy changes toxicity: grade 3 or 4 diarrhoea compared with chemotherapy alone (very low certainty).

2 findings from 1 review

Anti‐EGFR antibody plus chemotherapy vs chemotherapy alone

Grade ≥ 3 diarrhoea · treatment of relapsed epithelial ovarian cancer

It is very uncertain whether anti‐EGFR antibody plus chemotherapy changes toxicity: grade 3 or 4 diarrhoea ‐ seribantumab compared with chemotherapy alone (very low certainty).

1 finding from 1 review

Anti‐EGFR antibody plus chemotherapy vs chemotherapy alone

Toxicity: grade 3 or 4 nausea ± vomiting · treatment of relapsed epithelial ovarian cancer

Anti‐EGFR antibody plus chemotherapy showed no clear difference in toxicity: grade 3 or 4 nausea ± vomiting compared with chemotherapy alone (low certainty).

1 finding from 1 review

Maintenance chemotherapy vs observation

Progression‐free survival · patients with epithelial ovarian cancer

Maintenance chemotherapy showed no clear difference in 3‐year PFS compared with observation (moderate certainty).

3 findings from 1 review