Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
Intralesional betamethasone showed no clear difference in pain (mean score) compared with intralesional triamcinolone acetonide (low certainty).
1 finding from 1 review
Behaviour · Children and adolescents (0 to 16 years) needing dental treatment
1 finding from 1 review
Clinical score · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
It is very uncertain whether systemic (oral) betamethasone changes clinical score compared with topical triamcinolone acetonide paste (very low certainty).
1 finding from 1 review
Pain resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
It is very uncertain whether systemic (oral) betamethasone changes pain resolution compared with topical triamcinolone acetonide paste (very low certainty).
1 finding from 1 review
Pain / clinical response (not analysable) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review
Probing pocket depth · Adults with periodontitis (chronic and aggressive)
Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with SRP; GRADE not reported.
3 findings from 1 review
MD -0.47 [-0.68, -0.26]
6 studies · 215 participants
GRADE not reported
MD -0.18 [-0.33, -0.04]
15 studies · 562 participants
GRADE not reported
MD -0.30 [-0.42, -0.18]
2 studies · 389 participants
Very low
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review
Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive)
Amoxicillin + metronidazole + SRP led to lower percentage of bleeding on probing (BOP) compared with SRP; GRADE not reported.
3 findings from 1 review
MD -2.05 [-2.98, -1.11]
13 studies · 460 participants
GRADE not reported
MD -5.32 [-12.02, 1.37]
5 studies · 172 participants
GRADE not reported
MD -8.06 [-14.26, -1.85]
2 studies · 389 participants
Very low
Probing pocket depth · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP led to lower probing pocket depth compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether amoxicillin + metronidazole + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.47 [-0.90, -0.05]
2 studies · 389 participants
Very low
MD -0.21 [-0.41, -0.01]
13 studies · 501 participants
GRADE not reported
MD -0.04 [-0.35, 0.26]
6 studies · 215 participants
GRADE not reported
Adverse events · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in adverse events compared with clarithromycin + SRP; GRADE not reported.
1 finding from 1 review
Percentage of closed pockets · Adults with periodontitis (chronic and aggressive)
Amoxicillin + metronidazole + SRP led to lower percentage of closed pockets compared with SRP; GRADE not reported.
3 findings from 1 review
MD -13.90 [-24.16, -3.64]
1 study · 44 participants
GRADE not reported
MD -16.20 [-25.87, -6.53]
1 study · 44 participants
Very low
MD -10.05 [-18.78, -1.32]
2 studies · 73 participants
GRADE not reported
Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive)
The review found no eligible studies for this question.
1 finding from 1 review
Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review
Antimicrobial resistance · Adults with periodontitis (chronic and aggressive)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether amoxicillin + metronidazole + SRP changes adverse events compared with SRP (very low certainty).
1 finding from 1 review
Most common adverse events were mild gastrointestinal disturbances, nausea and vomiting, metallic taste, and diarrhoea in the intervention group. Control group reported adverse events like hypothermia, mild…
2 studies · 389 participants
Very low
Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
Donatsky 1982 (crossover, n=15, Sjogren's syndrome): CMC spray had a similar effect on oral dryness to the spray base, but was more effective than water. Paired crossover data not presented; effect size not estimable.
1 study · 15 participants
GRADE not reported
Oral health (plaque and gingival indices) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
Andersson 1995 (crossover, n=20): more participants experienced a reduction in oral dryness with linseed (Salinum) spray than with CMC spray; crossover data not accounted for, no usable estimate.
1 study · 20 participants
GRADE not reported
Patient preference · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
Statistically significant preference for linseed spray: of 17 with a preference, more favoured linseed (Chi2 4.77, df=1; P = 0.029); 3 expressed no preference.
1 study · 20 participants
GRADE not reported