Findings

What do systematic reviews say?

149 questions · 157 findings · 43 reviews · Airways

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No studies found 4 · 2.5%GRADE not reported 6 · 3.8%Very low 10 · 6.4%Low 71 · 45.2%Moderate 48 · 30.6%High 18 · 11.5%

Physical exercise training vs control

Change from baseline in 6MWT (metres) · people in the post‐acute period following acute exacerbation of bronchiectasis

1 finding from 1 review

Exercise training for bronchiectasis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 27 participants
Low

Titrated oxygen therapy vs high‐flow oxygen therapy

Mortality (respiratory‐ related and all‐cause · adults with acute exacerbations of chronic obstructive pulmonary disease

Titrated oxygen therapy may leads to lower mortality (respiratory‐ related and all‐cause compared with high‐flow oxygen therapy (low certainty).

1 finding from 1 review

Oxygen therapy in the pre‐hospital setting for acute exacerbations of chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
RR 0.22 [0.05, 0.97]
1 study · 214 participants
Low

Titrated oxygen therapy vs high‐flow oxygen therapy

Arterial blood gas (pH) · adults with acute exacerbations of chronic obstructive pulmonary disease

1 finding from 1 review

Oxygen therapy in the pre‐hospital setting for acute exacerbations of chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 214 participants
Low

Titrated oxygen therapy vs high‐flow oxygen therapy

Ventilation of any type · adults with acute exacerbations of chronic obstructive pulmonary disease

Titrated oxygen therapy showed no clear difference in ventilation of any type compared with high‐flow oxygen therapy (low certainty).

1 finding from 1 review

Oxygen therapy in the pre‐hospital setting for acute exacerbations of chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
RR 0.67 [0.29, 1.55]
1 study · 189 participants
Low

Titrated oxygen therapy vs high‐flow oxygen therapy

Length of hospital stay · adults with acute exacerbations of chronic obstructive pulmonary disease

1 finding from 1 review

Oxygen therapy in the pre‐hospital setting for acute exacerbations of chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 214 participants
Low

Titrated oxygen therapy vs high‐flow oxygen therapy

Quality of life ‐ not measured · adults with acute exacerbations of chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review

Oxygen therapy in the pre‐hospital setting for acute exacerbations of chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Titrated oxygen therapy vs high‐flow oxygen therapy

Lung function ‐ not measured · adults with acute exacerbations of chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review

Oxygen therapy in the pre‐hospital setting for acute exacerbations of chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Titrated oxygen therapy vs high‐flow oxygen therapy

Dyspnoea score ‐ not measured · adults with acute exacerbations of chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review

Oxygen therapy in the pre‐hospital setting for acute exacerbations of chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Adults: higher dose/longer course vs lower dose/shorter course

Re‐admission during · Adults with acute asthma

Adults: higher dose/longer course showed no clear difference in re‐admission in compared with lower dose/shorter course (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 1.35 [0.38, 4.79]
4 studies · 142 participants
Low

Children: higher dose/longer course vs lower dose/shorter course

Re‐admission during · children with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 98 participants
Very low

Children: higher dose/longer course vs lower dose/shorter course

Asthma symptoms · children with acute asthma

Children: higher dose/longer course showed no clear difference in asthma symptoms Symptom free by 7 days compared with lower dose/shorter course (moderate certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 1.22 [0.67, 2.19]
1 study · 201 participants
Moderate

Children: higher dose/longer course vs lower dose/shorter course

Serious adverse events · children with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 201 participants
GRADE not reported

Children: higher dose/longer course vs lower dose/shorter course

Exacerbations · children with acute asthma

Children: higher dose/longer course showed no clear difference in new exacerbation during compared with lower dose/shorter course (low certainty).

2 findings from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 1.38 [0.25, 7.47]
2 studies · 231 participants
Low
Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 2.17 [0.67, 7.01]
1 study · 100 participants
Very low

Children: higher dose/longer course vs lower dose/shorter course

FEV1 % predicted · children with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
GRADE not reported

Children: higher dose/longer course vs lower dose/shorter course

All adverse events · children with acute asthma

Children: higher dose/longer course showed no clear difference in all adverse events compared with lower dose/shorter course (moderate certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.67 [0.11, 4.08]
1 study · 201 participants
Moderate

Adults: higher dose/longer course vs lower dose/shorter course

Asthma severity and symptoms · Adults with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Adults: higher dose/longer course vs lower dose/shorter course

Asthma symptoms Complete resolution by day 28 · Adults with acute asthma

Adults: higher dose/longer course showed no clear difference in asthma symptoms Complete resolution by day 28 compared with lower dose/shorter course (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.55 [0.13, 2.26]
1 study · 35 participants
Low

Adults: higher dose/longer course vs lower dose/shorter course

Exacerbations · Adults with acute asthma

It is very uncertain whether adults: higher dose/longer course changes new exacerbation in compared with lower dose/shorter course (very low certainty).

2 findings from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.98 [0.17, 5.56]
2 studies · 55 participants
Very low
Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.62 [0.23, 1.68]
3 studies · 122 participants
Low

Adults: higher dose/longer course vs lower dose/shorter course

FEV1 % predicted · Adults with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 41 participants
Very low

Adults: higher dose/longer course vs lower dose/shorter course

All adverse events · Adults with acute asthma

It is very uncertain whether adults: higher dose/longer course changes all adverse events compared with lower dose/shorter course (very low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 4.15 [0.94, 18.41]
1 study · 43 participants
Very low