What do systematic reviews say?

Short interval vs long interval

Short interval may leads to lower pregnancy rate per couple ‐ 24 hours versus 34 to 36 hours compared with long interval (low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 0.55 [0.31, 0.98]
  2 studies · 234 participants
  Low
• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 0.44 [0.1, 1.92]
  1 study · 30 participants
  Low
• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 0.58 [0.14, 2.48]
  1 study · 30 participants
  Low

Short interval vs long interval

It is very uncertain whether short interval changes miscarriage rate per pregnancy ‐ 24 hours versus 34 to 36 hours compared with long interval (very low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 1.58 [0.35, 7.16]
  2 studies · 67 participants
  Very low
• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 4 [0.27, 58.56]
  1 study · 15 participants
  Very low
• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 1.33 [0.07, 25.91]
  1 study · 16 participants
  Very low

hCG vs GnRH agonist

hCG showed no clear difference in live birth rate per couple compared with gnRH‐a (low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 1.04 [0.42, 2.56]
  3 studies · 104 participants
  Low

hCG vs GnRH agonist

hCG showed no clear difference in pregnancy rate per couple compared with gnRH‐a (low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 1.14 [0.63, 2.08]
  4 studies · 206 participants
  Low

hCG vs GnRH agonist

It is very uncertain whether hCG changes multiple pregnancy rate per pregnancy compared with gnRH‐a (very low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 0.15 [0.02, 1.38]
  4 studies · 74 participants
  Very low

hCG vs GnRH agonist

It is very uncertain whether hCG changes miscarriage rate per pregnancy compared with gnRH‐a (very low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 1.72 [0.48, 6.2]
  4 studies · 74 participants
  Very low

hCG vs LH surge

hCG showed no clear difference in pregnancy rate per couple compared with LH surge (low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 1.33 [0.72, 2.45]
  4 studies · 275 participants
  Low

hCG vs GnRH agonist

hCG showed no clear difference in OHSS per cycle compared with gnRH‐a (low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 2.27 [0.65, 7.91]
  3 studies · 456 participants
  Low

Early hCG vs late hCG

Early hCG showed no clear difference in pregnancy rate per couple compared with late hCG (low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 1.32 [0.77, 2.25]
  1 study · 612 participants
  Low

Early hCG vs late hCG

It is very uncertain whether early hCG changes miscarriage rate compared with late hCG (very low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 0.51 [0.08, 3.28]
  1 study · 65 participants
  Very low

Intervention not reported

It is very uncertain whether the intervention changes pregnancy rate per couple (very low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 1.38 [0.28, 6.71]
  1 study · 66 participants
  Very low

hCG vs LH surge

It is very uncertain whether hCG changes multiple pregnancy rate per pregnancy compared with LH surge (very low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 1.12 [0.17, 7.6]
  2 studies · 42 participants
  Very low

u‐hCG vs r‐hCG

u‐hCG showed no clear difference in live birth rate per couple compared with r‐hCG (low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 1.17 [0.68, 2.03]
  1 study · 284 participants
  Low

u‐hCG vs r‐hCG

u‐hCG showed no clear difference in pregnancy rate per couple compared with r‐hCG (low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 1.02 [0.65, 1.57]
  2 studies · 409 participants
  Low

u‐hCG vs r‐hCG

u‐hCG showed no clear difference in multiple pregnancy rate per pregnancy compared with r‐hCG (low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 0.99 [0.4, 2.47]
  2 studies · 109 participants
  Low

u‐hCG vs r‐hCG

It is very uncertain whether u‐hCG changes miscarriage rate per pregnancy compared with r‐hCG (very low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 0.57 [0.13, 2.47]
  2 studies · 109 participants
  Very low

u‐hCG vs r‐hCG

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 468 participants
  Moderate

Short interval vs long interval

Short interval showed no clear difference in live birth rate per couple ‐ 24 hours versus 34 to 36 hours compared with long interval (low certainty).

• Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
  OR 0.52 [0.27, 1]
  1 study · 204 participants
  Low

Soft catheters vs Firm catheters

Soft catheters showed no clear difference in live birth rate compared with firm catheters (low certainty).

• Soft versus firm catheters for intrauterine insemination 2010 · Cochrane Headline outcomes only
  OR 0.94 [0.65, 1.35]
  3 studies · 896 participants
  Low

Soft catheters vs Firm catheters

It is very uncertain whether soft catheters changes pregnancy rate compared with firm catheters (very low certainty).

• Soft versus firm catheters for intrauterine insemination 2010 · Cochrane Headline outcomes only
  OR 1 [0.73, 1.35]
  6 studies · 1210 participants
  Very low