Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

154 questions · 161 findings · 14 reviews · Neuromuscular

No studies found 47 · 29.2%GRADE not reported 7 · 4.3%Very low 52 · 32.3%Low 33 · 20.5%Moderate 13 · 8.1%High 9 · 5.6%

Intensive insulin therapy vs conventional insulin therapy

Occurrence of CIP/CIM ‐ in the total population randomised · critically ill patients

Intensive insulin therapy may leads to lower occurrence of CIP/CIM ‐ in total population randomised compared with conventional insulin therapy (low certainty).

1 finding from 1 review

Corticosteroids vs placebo compared

Serious adverse events (dichotomous data) ‐ suspected or probable pneumonia · critically ill patients

Corticosteroids showed no clear difference in serious adverse events (dichotomous data) ‐ suspected or probable… compared with placebo compared (high certainty).

1 finding from 1 review

Electrical muscle stimulation vs control

Occurrence of CIP/CIM ‐ in the total population randomised · critically ill patients

It is very uncertain whether electrical muscle stimulation changes occurrence of CIP/CIM ‐ in the total population randomised compared with control (very low certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Occurrence of CIP/CIM ‐ in screened population · critically ill patients

Intensive insulin therapy probably leads to lower occurrence of CIP/CIM ‐ in screened population compared with conventional insulin therapy (moderate certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Death ‐ at 30 days after ICU admission, in total population randomised · critically ill patients

Intensive insulin therapy showed no clear difference in death ‐ at 30 days after ICU admission, in total population randomised compared with conventional insulin therapy (high certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Death ‐ at 180 days after ICU admission, in total population randomised · critically ill patients

Intensive insulin therapy showed no clear difference in death ‐ at 180 days after ICU admission, in total population… compared with conventional insulin therapy (moderate certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Serious adverse events, ‐ in total population randomised ‐ hypoglycaemia · critically ill patients

Intensive insulin therapy leads to higher serious adverse events, ‐ in total population randomised ‐… compared with conventional insulin therapy (high certainty).

1 finding from 1 review