Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,736 questions · 15,265 findings · 1,163 reviews · Headline outcomes only

No studies found 3,871 · 25.4%GRADE not reported 810 · 5.3%Very low 4,242 · 27.8%Low 3,879 · 25.4%Moderate 1,999 · 13.1%High 464 · 3%

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Primary health professional‐led or collaborative care vs usual or enhanced care

Depressive symptoms · women with perinatal depression

It is very uncertain whether primary health professional‐led collaborative care interventions changes depression symptoms ‐ intermediate term (1 to 6 months post… compared with usual or enhanced care (very low certainty).

1 finding from 1 review

Primary health professional‐led or collaborative care vs usual or enhanced care

Quality of life ‐ intermediate term (1 to 6 months post intervention) SF‐36 social functioning (higher score = higher quality of life) · women with perinatal depression

It is very uncertain whether primary health professional‐led collaborative care interventions changes quality of life ‐ intermediate term (1 to 6 months post… compared with usual or enhanced care (very low certainty).

1 finding from 1 review

Skin care intervention vs standard skin care or no skin care intervention

IgE‐mediated food allergy (oral food challenge) by 1 to 3 years · infants

Skin care intervention showed no clear difference in igE‐mediated food allergy (oral food challenge) by 1 to 3 years compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Skin care intervention vs standard skin care or no skin care intervention

Parent report of immediate reaction to common food allergen (at 2 years) · infants

Skin care intervention showed no clear difference in parent report of immediate reaction to common food allergen (at 2… compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Skin care intervention vs standard skin care or no skin care intervention

Allergic sensitisation to a food allergen (at 1 to 3 years) · infants

Skin care intervention showed no clear difference in allergic sensitisation to a food allergen (at 1 to 3 years) compared with standard skin care or no skin care intervention (low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Clinical recovery ‐ harmful or hazardous alcohol use (1 to 6 months post intervention) · adult patients with harmful or hazardous alcohol or substance use

Primary health professional‐ and community professional‐led… showed no clear difference in clinical recovery ‐ harmful or hazardous alcohol use (1 to 6 months… compared with enhanced usual care (moderate certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Cannabis use · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether primary health professional‐ and community professional‐led… changes prevalence of cannabis use (1 to 6 months post intervention) (RR < 1… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Clinical symptoms ‐ alcohol use (1 to 6 months post intervention) ‐ risk of hazardous or harmful alcohol use · adult patients with harmful or hazardous alcohol or substance use
1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Clinical symptoms ‐ overall risk of harmful or hazardous alcohol and substance use (1 to 6 months post intervention) · adult patients with harmful or hazardous alcohol or substance use
1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Quality of life (1 to 6 months post intervention) · adult patients with harmful or hazardous alcohol or substance use

Primary health professional‐ and community professional‐led… showed no clear difference in quality of life (1 to 6 months post intervention) compared with enhanced usual care (moderate certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Service utilisation (1 to 6 months post intervention) ‐ incidence of visits to primary care centres due to alcohol consumption (RR > 1 denotes greater risk) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether primary health professional‐ and community professional‐led… changes service utilisation (1 to 6 months post intervention) ‐ incidence of… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Adverse events (1 to 6 months post intervention) ‐ incidence of alcohol‐related consequences ‐ accidents (RR > 1 denotes greater risk) · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether primary health professional‐ and community professional‐led… changes adverse events (1 to 6 months post intervention) ‐ incidence of… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Clinical symptoms ‐ alcohol use (1 to 6 months post intervention) · adult patients with substance dependence

It is very uncertain whether primary health professional‐ and community professional‐led… changes clinical symptoms ‐ alcohol use (< 1 month post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Clinical symptoms ‐ drug use (< 1 month post intervention) ‐ heroin · adult patients with substance dependence

It is very uncertain whether primary health professional‐ and community professional‐led… changes clinical symptoms ‐ drug use (< 1 month post intervention) ‐ heroin compared with enhanced usual care (very low certainty).

1 finding from 1 review