Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

231 questions · 236 findings · 32 reviews · Gynaecology and Fertility

No studies found 31 · 13.1%GRADE not reported 5 · 2.1%Very low 74 · 31.4%Low 91 · 38.6%Moderate 35 · 14.8%High 0 · 0%

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

Live birth rate · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

It is very uncertain whether recombinant luteinizing hormone (rLH) combined with recombinant… changes live birth rate compared with rFSH alone (very low certainty).

1 finding from 1 review

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

OHSS · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Recombinant luteinizing hormone (rLH) combined with recombinant… showed no clear difference in OHSS incidence compared with rFSH alone (low certainty).

1 finding from 1 review

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

Ongoing pregnancy · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Recombinant luteinizing hormone (rLH) combined with recombinant… probably leads to higher ongoing pregnancy rate compared with rFSH alone (moderate certainty).

1 finding from 1 review

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

Miscarriage · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Recombinant luteinizing hormone (rLH) combined with recombinant… showed no clear difference in miscarriage rate compared with rFSH alone (moderate certainty).

1 finding from 1 review

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

Cancellation rate for low response · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

Recombinant luteinizing hormone (rLH) combined with recombinant… showed no clear difference in cancellation rate for low response compared with rFSH alone (low certainty).

1 finding from 1 review

Recombinant luteinizing hormone (rLH) combined with recombinant follicle‐stimulating hormone (rFSH) vs rFSH alone

Cancellation rate for imminent OHSS · Women undergoing ovarian stimulation with gonadotrophins in IVF and ICSI procedures

It is very uncertain whether recombinant luteinizing hormone (rLH) combined with recombinant… changes cancellation rate for imminent OHSS compared with rFSH alone (very low certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Mean number of gonadotropin ampoules used per woman · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)
1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Mean number of oocytes retrieved per woman · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)
1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Live birth rate per woman · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in live birth per woman compared with gonadotropins (with GnRH agonist or midcycle antagonist) (low certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonist or midcycle antagonist) (low certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Cancellation rate per woman · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)

Clomiphene citrate or letrozole with or without gonadotropins (with… may leads to higher cancellation rate per woman compared with gonadotropins (with GnRH agonist or midcycle antagonist) (low certainty).

1 finding from 1 review