Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

132 questions · 147 findings · 29 reviews · Neonatal

No studies found 41 · 27.9%GRADE not reported 4 · 2.7%Very low 29 · 19.7%Low 43 · 29.3%Moderate 19 · 12.9%High 11 · 7.5%

Anti‐vascular endothelial growth factor therapy combined with laser/cryotherapy vs conventional laser/cryotherapy

Structural outcome ‐ retinal detachment · preterm infants with type 1 ROP

Anti‐vascular endothelial growth factor therapy combined with… may leads to lower structural outcome ‐ retinal detachment (unit of analysis: eyes) compared with laser/cryotherapy (low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy combined with laser/cryotherapy vs conventional laser/cryotherapy

Local adverse effects ‐ perioperative retinal haemorrhages (unit of analysis: eyes) · preterm infants with type 1 ROP

It is very uncertain whether anti‐vascular endothelial growth factor therapy combined with… changes local adverse effects ‐ perioperative retinal haemorrhages (unit of… compared with laser/cryotherapy (very low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy combined with laser/cryotherapy vs conventional laser/cryotherapy

Recurrence of ROP by 55 weeks' PMA · preterm infants with type 1 ROP

Anti‐vascular endothelial growth factor therapy combined with… may leads to lower recurrence of ROP by 55 weeks' postmenstrual age compared with laser/cryotherapy (low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy vs conventional laser/cryotherapy

Structural outcome ‐ complete retinal detachment (unit of analysis: eyes) · preterm infants with type 1 ROP

It is very uncertain whether anti‐vascular endothelial growth factor therapy changes structural outcome ‐ complete retinal detachment (unit of analysis:… compared with conventional laser/cryotherapy (very low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy vs conventional laser/cryotherapy

Refractive error ‐ very high myopia ‐ at 30 months of age (unit of analysis: eyes) · preterm infants with type 1 ROP

Anti‐vascular endothelial growth factor therapy may leads to lower refractive error ‐ very high myopia ‐ at 30 months of age (unit of… compared with conventional laser/cryotherapy (low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy vs conventional laser/cryotherapy

Mortality before hospital discharge · preterm infants with type 1 ROP

Anti‐vascular endothelial growth factor therapy showed no clear difference in mortality before discharge from primary hospital compared with conventional laser/cryotherapy (low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy vs conventional laser/cryotherapy

Mortality at 30 months of age · preterm infants with type 1 ROP

Anti‐vascular endothelial growth factor therapy showed no clear difference in mortality at 30 months of age compared with conventional laser/cryotherapy (low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy vs conventional laser/cryotherapy

Local adverse effects ‐ corneal opacity requiring corneal transplant (unit of analysis: eyes) · preterm infants with type 1 ROP

It is very uncertain whether anti‐vascular endothelial growth factor therapy changes local adverse effects ‐ corneal opacity requiring corneal transplant… compared with conventional laser/cryotherapy (very low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy vs conventional laser/cryotherapy

Local adverse effects ‐ lens opacity requiring cataract removal (unit of analysis: eyes) · preterm infants with type 1 ROP

It is very uncertain whether anti‐vascular endothelial growth factor therapy changes local adverse effects ‐ lens opacity requiring cataract removal… compared with conventional laser/cryotherapy (very low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy vs conventional laser/cryotherapy

Recurrence of ROP (up to 6 months of age) · preterm infants with type 1 ROP

It is very uncertain whether anti‐vascular endothelial growth factor therapy changes recurrence of ROP (up to 6 months of age) compared with conventional laser/cryotherapy (very low certainty).

1 finding from 1 review

Anti‐vascular endothelial growth factor therapy vs conventional laser/cryotherapy

Recurrence of ROP (unit of analysis: eyes) · preterm infants with type 1 ROP

It is very uncertain whether anti‐vascular endothelial growth factor therapy changes recurrence of ROP (unit of analysis: eyes) compared with conventional laser/cryotherapy (very low certainty).

1 finding from 1 review