What do systematic reviews say?

Oral vs intravenous acetylcysteine

The review found no eligible studies for this question.

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral vs intravenous acetylcysteine

It is very uncertain whether oral changes nausea compared with intravenous acetylcysteine (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 2.71 [1, 7.38]
  1 study · 66 participants
  Very low

Oral vs intravenous acetylcysteine

It is very uncertain whether oral changes vomiting compared with intravenous acetylcysteine (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 2.1 [0.62, 7.12]
  1 study · 66 participants
  Very low

Intravenous acetylcysteine vs placebo

Intravenous acetylcysteine may leads to lower mortality compared with placebo (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 0.29 [0.09, 0.94]
  1 study · 50 participants
  Low

Initial infusion rate of intravenous acetylcysteine over 15 minutes vs 60 minutes

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 180 participants
  Very low

Methionine and supportive treatment vs supportive treatment

Methionine and supportive treatment may leads to lower hepatotoxicity compared with supportive treatment (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.05 [0.01, 0.53]
  1 study · 26 participants
  Low

Initial infusion rate of intravenous acetylcysteine over 15 minutes vs 60 minutes

It is very uncertain whether initial infusion rate of intravenous acetylcysteine over 15 minutes changes hepatotoxicity compared with 60 minutes (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 1.34 [0.39, 4.56]
  1 study · 175 participants
  Very low

Initial infusion rate of intravenous acetylcysteine over 15 minutes vs 60 minutes

Initial infusion rate of intravenous acetylcysteine over 15 minutes may leads to lower any adverse event compared with 60 minutes (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  OR 0.51 [0.27, 0.96]
  1 study · 180 participants
  Low

Oral plus intravenous acetylcysteine vs intravenous acetylcysteine

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Very low

Oral plus intravenous acetylcysteine vs intravenous acetylcysteine

The review found no eligible studies for this question.

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Charcoal haemoperfusion vs no intervention

It is very uncertain whether charcoal haemoperfusion changes mortality compared with no intervention (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 7.39 [0.15, 372.38]
  1 study · 16 participants
  Very low

Cysteamine vs no intervention

It is very uncertain whether cysteamine changes mortality compared with no intervention (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 0.53 [0.05, 5.22]
  2 studies · 65 participants
  Very low

Cysteamine vs dimercaprol

It is very uncertain whether cysteamine changes mortality compared with dimercaprol (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 0.14 [0, 6.82]
  1 study · 52 participants
  Very low

Cysteamine vs methionine (randomised trials)

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 27 participants
  Very low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 222 participants
  Very low

Gemcitabine plus vandetanib vs vandetanib

The review found no eligible studies for this question.

• Gemcitabine‐based chemotherapy for advanced biliary tract carcinomas 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Gemcitabine vs vandetanib

It is very uncertain whether gemcitabine changes overall response rate compared with vandetanib (very low certainty).

• Gemcitabine‐based chemotherapy for advanced biliary tract carcinomas 2018 · Cochrane Headline outcomes only
  RR 3.77 [0.82, 17.33]
  1 study · 108 participants
  Very low

Gemcitabine vs vandetanib

The review found no eligible studies for this question.

• Gemcitabine‐based chemotherapy for advanced biliary tract carcinomas 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Gemcitabine vs vandetanib

It is very uncertain whether gemcitabine changes grade 1 ‐ 4 anaemia compared with vandetanib (very low certainty).

• Gemcitabine‐based chemotherapy for advanced biliary tract carcinomas 2018 · Cochrane Headline outcomes only
  RR 7.38 [0.94, 58.05]
  1 study · 115 participants
  Very low

Gemcitabine plus cisplatin vs S‐1 plus cisplatin

It is very uncertain whether gemcitabine plus cisplatin changes all‐cause mortality at 1 year compared with S‐1 plus cisplatin (very low certainty).

• Gemcitabine‐based chemotherapy for advanced biliary tract carcinomas 2018 · Cochrane Headline outcomes only
  RR 0.76 [0.58, 0.98]
  1 study · 96 participants
  Very low