Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

294 questions · 295 findings · 16 reviews · Schizophrenia

No studies found 79 · 26.8%GRADE not reported 32 · 10.8%Very low 99 · 33.6%Low 55 · 18.6%Moderate 17 · 5.8%High 13 · 4.4%

HALOPERIDOL vs ZIPRASIDONE

Adverse effects: Specific ‐ dystonia between 0‐3 days (IM phase) · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ dystonia during 72 hours compared with OTHER ANTIPSYCHOTIC: j. ZIPRASIDONE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs ZIPRASIDONE

Adverse effects: Specific ‐ clinically significant abnormal ECG during 72 hours · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ clinically significant abnormal ECG… compared with OTHER ANTIPSYCHOTIC: j. ZIPRASIDONE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: j. ZUCLOPENTHIXOL ACETATE

Repeated need for rapid tranquillisation ‐ more than 3 injections · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes repeated need for rapid tranquillisation ‐ more than 3 injections compared with OTHER ANTIPSYCHOTIC: k. ZUCLOPENTHIXOL ACETATE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: j. ZUCLOPENTHIXOL ACETATE

Tremor · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ tremor by 7 days compared with OTHER ANTIPSYCHOTIC: k. ZUCLOPENTHIXOL ACETATE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs ARIPIPRAZOLE

Repeated need for rapid tranquillisation ‐ needing additional injection · patients with psychosis‐induced aggression or agitation

HALOPERIDOL may leads to lower repeated need for rapid tranquillisation ‐ needing additional… compared with OTHER ANTIPSYCHOTIC: a. ARIPIPRAZOLE (low certainty).

1 finding from 1 review

HALOPERIDOL vs BENZODIAZEPINE: a. FLUNITRAZEPAM

Specific behaviours ‐ Aggression 50% reduction in OAS score at 90 minutes · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes specific behaviours ‐ aggression 50% reduction in OAS score at 90… compared with BENZODIAZEPINE: a. FLUNITRAZEPAM (very low certainty).

1 finding from 1 review

HALOPERIDOL vs lorazepam

Repeated need for rapid tranquillisation ‐ more than 1 injection · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes repeated need for rapid tranquillisation more than 1 injection compared with BENZODIAZEPINE: b. LORAZEPAM (very low certainty).

1 finding from 1 review