Findings

What do systematic reviews say?

203 questions · 208 findings · 26 reviews · Neonatal

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No studies found 3 · 1.4%GRADE not reported 23 · 11.1%Very low 59 · 28.4%Low 107 · 51.4%Moderate 12 · 5.8%High 4 · 1.9%

MFS‐LE vs S‐LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

MFS‐LE showed no clear difference in any sepsis (clinical and/or culture positive) compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1.11 [0.31, 4.02]
1 study · 57 participants
Low

OS‐LE vs S‐LE

Death of baby (up to discharge) · Parenterally fed preterm infants

OS‐LE showed no clear difference in death before discharge(incidence) compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1 [0.21, 4.82]
3 studies · 224 participants
Low

OS‐LE vs S‐LE

Days to regain birth weight · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 223 participants
Low

OS‐LE vs S‐LE

Rate of weight gain (g/kg/day) · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 123 participants
Low

OS‐LE vs S‐LE

Bronchopulmonary dysplasia/chronic lung disease · Parenterally fed preterm infants

It is very uncertain whether OS‐LE changes bronchopulmonary dysplasia/chronic lung disease (incidence ‐… compared with S‐LE (very low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.69 [0.46, 1.04]
4 studies · 261 participants
Very low

OS‐LE vs S‐LE

Long‐term complications (bronchopulmonary dysplasia, chronic lung disease) · Parenterally fed preterm infants

OS‐LE showed no clear difference in bronchopulmonary dysplasia/chronic lung disease (sensitivity analysis) compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1.01 [0.57, 1.79]
3 studies · 197 participants
Low

OS‐LE vs S‐LE

Duration of mechanical ventilation · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 202 participants
Very low

MOFS‐LE vs S‐LE

Days to regain birth weight · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 234 participants
Low

OS‐LE vs S‐LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

It is very uncertain whether OS‐LE changes any sepsis (clinical and/or culture positive) compared with S‐LE (very low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 0.87 [0.56, 1.36]
5 studies · 301 participants
Very low

MS‐LE vs S‐LE

Mortality before hospital discharge · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
GRADE not reported

MS‐LE vs S‐LE

Days to regain birth weight · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

MS‐LE vs S‐LE

Rate of weight gain (g/kg/day) · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

MS‐LE vs S‐LE

Bronchopulmonary dysplasia/chronic lung disease · Parenterally fed preterm infants

It is very uncertain whether MS‐LE changes bronchopulmonary dysplasia/chronic lung disease compared with S‐LE (very low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1 [0.28, 3.63]
1 study · 60 participants
Very low

MS‐LE vs S‐LE

Any sepsis (clinical and/or culture positive) · Parenterally fed preterm infants

It is very uncertain whether MS‐LE changes any sepsis (clinical and/or culture positive) compared with S‐LE (very low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 2 [0.67, 5.94]
1 study · 60 participants
Very low

MS‐LE vs S‐LE

Hypertriglyceridaemia · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 12 participants
GRADE not reported

Fish oil lipid emulsion (LE) vs S‐LE

Mortality before hospital discharge · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in death before discharge compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1.28 [0.69, 2.35]
5 studies · 399 participants
Low

Fish oil lipid emulsion (LE) vs S‐LE

Days to regain birth weight · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 261 participants
Low

MOFS‐LE vs S‐LE

Rate of weight gain (g/kg/day) · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 347 participants
Very low

Fish oil lipid emulsion (LE) vs S‐LE

Rate of weight gain (g/kg/day) · Parenterally fed preterm infants

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 374 participants
Very low

Fish oil lipid emulsion (LE) vs S‐LE

Bronchopulmonary dysplasia/chronic lung disease · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in bronchopulmonary dysplasia/chronic lung disease compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
RR 1.02 [0.7, 1.5]
4 studies · 341 participants
Low