Resolution of fever within 48 hours · adults and adolescents with scrub typhus
It is very uncertain whether macrolides changes resolution of fever within 48 hours compared with doxycycline (very low certainty).
1 finding from 1 review
Resolution of fever within 5 days · adults and adolescents with scrub typhus
Macrolides showed no clear difference in resolution of fever within 5 days compared with doxycycline (low certainty).
1 finding from 1 review
Time to defervescence · adults and adolescents with scrub typhus
1 finding from 1 review
Clinical malaria · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine showed no clear difference in clinical malaria compared with doxycycline; GRADE not reported.
1 finding from 1 review
Serious adverse effects · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine showed no clear difference in serious adverse effects compared with doxycycline; GRADE not reported.
1 finding from 1 review
Discontinuation of treatment due to side effects ( · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine showed no clear difference in discontinuations due to adverse effects compared with doxycycline; GRADE not reported.
1 finding from 1 review
Abnormal dreams · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine led to higher abnormal dreams compared with doxycycline; GRADE not reported.
1 finding from 1 review
Insomnia · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine led to higher insomnia compared with doxycycline; GRADE not reported.
1 finding from 1 review
Anxiety · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine led to higher anxiety compared with doxycycline; GRADE not reported.
1 finding from 1 review
Depressed mood · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine led to higher depressed mood compared with doxycycline; GRADE not reported.
1 finding from 1 review
Abnormal thoughts or perceptions · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine showed no clear difference in abnormal thoughts or perceptions compared with doxycycline; GRADE not reported.
1 finding from 1 review
Nausea · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine led to lower nausea compared with doxycycline; GRADE not reported.
1 finding from 1 review
Vomiting · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine led to lower vomiting compared with doxycycline; GRADE not reported.
1 finding from 1 review
Abdominal pain · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine showed no clear difference in abdominal pain compared with doxycycline; GRADE not reported.
1 finding from 1 review
Diarrhoea · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine led to lower diarrhoea compared with doxycycline; GRADE not reported.
1 finding from 1 review
Dyspepsia · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine led to lower dyspepsia compared with doxycycline; GRADE not reported.
1 finding from 1 review
Headache · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine showed no clear difference in headache compared with doxycycline; GRADE not reported.
1 finding from 1 review
Dizziness · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine showed no clear difference in dizziness compared with doxycycline; GRADE not reported.
1 finding from 1 review
Visual impairment · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine led to higher visual impairment compared with doxycycline; GRADE not reported.
1 finding from 1 review
Pruritis · Non‐immune adults and children travelling to malaria‐endemic settings
Mefloquine led to lower pruritis compared with doxycycline; GRADE not reported.
1 finding from 1 review