Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

139 questions · 147 findings · 16 reviews · Headline outcomes only

No studies found 21 · 14.3%GRADE not reported 4 · 2.7%Very low 26 · 17.7%Low 61 · 41.5%Moderate 29 · 19.7%High 6 · 4.1%

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

CKD or death: 50% decline in GFR by 78 weeks · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in CKD or death: 50% decline in GFR by 78 weeks compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Adverse effects (weeks 0 to 26): serious infection requiring hospitalisation · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in adverse events (weeks 0 to 26): serious infection requiring… compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Adverse events: hypertension · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in adverse events (weeks 0 to 26): hypertension compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review

IV cyclophosphamide vs IV dexamethasone and oral cyclophosphamide

Complete remission (no further aphthous episodes to 6 months) · idiopathic steroid‐resistant nephrotic syndrome in children

IV cyclophosphamide showed no clear difference in treatment response at 6 months: complete remission compared with oral cyclophosphamide plus IV dexamethasone (low certainty).

1 finding from 1 review

IV cyclophosphamide vs IV dexamethasone and oral cyclophosphamide

Treatment response at 6 months: partial remission · idiopathic steroid‐resistant nephrotic syndrome in children

IV cyclophosphamide showed no clear difference in treatment response at 6 months: partial remission compared with oral cyclophosphamide plus IV dexamethasone (low certainty).

1 finding from 1 review

IV cyclophosphamide vs IV dexamethasone and oral cyclophosphamide

Complete or partial remission · idiopathic steroid‐resistant nephrotic syndrome in children

IV cyclophosphamide showed no clear difference in treatment response at 6 months: complete or partial remission compared with oral cyclophosphamide plus IV dexamethasone (low certainty).

1 finding from 1 review

IV cyclophosphamide vs IV dexamethasone and oral cyclophosphamide

Treatment response at 18 months ‐ Sustained remission/steroid sensitive relapses Clinical assessment · idiopathic steroid‐resistant nephrotic syndrome in children

IV cyclophosphamide showed no clear difference in treatment response at 18 months: sustained… compared with oral cyclophosphamide plus IV dexamethasone (low certainty).

1 finding from 1 review

IV cyclophosphamide vs IV dexamethasone and oral cyclophosphamide

Treatment response at 18 months ‐ CKD clinical assessment · idiopathic steroid‐resistant nephrotic syndrome in children

IV cyclophosphamide showed no clear difference in treatment response at 18 months: CKD compared with oral cyclophosphamide plus IV dexamethasone (low certainty).

1 finding from 1 review

IV cyclophosphamide vs IV dexamethasone and oral cyclophosphamide

Adverse effects ‐ Bacterial infection clinical assessment · idiopathic steroid‐resistant nephrotic syndrome in children

IV cyclophosphamide showed no clear difference in adverse events: bacterial infections compared with oral cyclophosphamide plus IV dexamethasone (low certainty).

1 finding from 1 review

Adults: prednisolone vs dexamethasone

Exacerbations · Adults with acute asthma

It is very uncertain whether adults: prednisolone changes new exacerbation during compared with dexamethasone (very low certainty).

2 findings from 1 review