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What do systematic reviews say?

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Evidence found and GRADE certainty

132 questions · 138 findings · 26 reviews · Headline outcomes only

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No studies found 23 · 16.7%GRADE not reported 8 · 5.8%Very low 24 · 17.4%Low 46 · 33.3%Moderate 23 · 16.7%High 14 · 10.1%

Fractional laser vs combined chemical peeling plus needling

Participant‐assessed adverse events (short‐term) N of participants with adverse events · people with acne scars

It is very uncertain whether fractional laser changes participant‐assessed adverse events (short‐term) N of participants… compared with combined chemical peeling plus needling (very low certainty).

1 finding from 1 review

Chemical peeling vs combined chemical peeling plus any active intervention

Participant‐reported scar improvement (long‐term) · people with acne scars

It is very uncertain whether chemical peeling changes participant‐reported scar improvement (long‐term) N of participants… compared with combined chemical peeling plus any active intervention (very low certainty).

1 finding from 1 review

Chemical peeling vs combined chemical peeling plus any active intervention

Participant‐assessed adverse events (short‐term) N of participants with adverse events · people with acne scars

It is very uncertain whether chemical peeling changes participant‐assessed adverse events (short‐term) N of participants… compared with combined chemical peeling plus any active intervention (very low certainty).

1 finding from 1 review