What do systematic reviews say?

Low‐level laser therapy vs Placebo (sham) laser therapy

The review found no eligible studies for this question.

• Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
  SoF row 'Adverse events': This outcome was not reported in the included studies.
  0 studies
  No studies found

Low‐level laser therapy vs Placebo (sham) laser therapy

The review found no eligible studies for this question.

• Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
  SoF row 'Pain': This outcome was not reported in the included studies.
  0 studies
  No studies found

Low‐level laser therapy vs Placebo (sham) laser therapy

The review found no eligible studies for this question.

• Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
  SoF row 'Taste': This outcome was not reported in the included studies.
  0 studies
  No studies found

Low‐level laser therapy vs Placebo (sham) laser therapy

Low-level laser therapy (photon-plus GaAlAs diode laser; 70 mW… showed no clear difference in thermosensory (thermal) perception compared with placebo (sham) laser therapy; GRADE not reported.

• Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
  MD 1.79 [-2.04, 5.62]
  2 studies · 25 participants
  GRADE not reported

Low‐level laser therapy vs Placebo (sham) laser therapy

The review found no eligible studies for this question.

• Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
  Results: no included study reported quality of life or patient satisfaction. In PUB2 patient satisfaction is merged with quality of life as 'quality of life/patient satisfaction'.
  0 studies
  No studies found

2 mm titanium plates vs 2.5 mm bioresorbable plates

2 mm titanium plates showed no clear difference in post-operative pain (residual pain, any severity) compared with 2.5 mm bioresorbable plates; GRADE not reported.

• Interventions for the management of mandibular fractures 2013 · Cochrane All outcomes

  1 month
  RR 1.26 [0.57, 2.82]
  1 study · 40 participants
  GRADE not reported

Camomile vs placebo

Camomile showed no clear difference in oral mucositis (any severity) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.89 [0.62, 1.27]
  1 study · 164 participants
  GRADE not reported

Sucralfate vs placebo or usual care

Sucralfate showed no clear difference in oral mucositis (any severity) compared with placebo/usual care (moderate certainty).

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.98 [0.88, 1.1]
  3 studies · 222 participants
  Moderate

Glutamine vs placebo or usual care

Glutamine showed no clear difference in oral mucositis (any severity) compared with placebo/usual care; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.78 [0.57, 1.08]
  5 studies
  GRADE not reported

Low‐level laser therapy vs Placebo or no active treatment

Laser (low level) showed no clear difference in oral mucositis (any severity) compared with placebo/sham/no treatment; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.91 [0.71, 1.17]
  5 studies · 234 participants
  GRADE not reported

Polaprezinc vs Azulene

Polaprezinc showed no clear difference in oral mucositis (any severity) compared with azulene; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.82 [0.63, 1.06]
  1 study · 31 participants
  GRADE not reported

Histamine gel vs placebo

Histamine gel showed no clear difference in oral mucositis (any severity) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 1.35 [0.91, 1.99]
  1 study · 39 participants
  GRADE not reported

Chlorhexidine vs placebo/no treatment

Chlorhexidine showed no clear difference in oral mucositis (any severity) compared with placebo/no treatment (low certainty).

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.76 [0.47, 1.24]
  4 studies · 454 participants
  Low

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Chlorhexidine showed no clear difference in oral mucositis (any severity) compared with cryotherapy (ice chips); GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 1.03 [0.76, 1.41]
  1 study · 133 participants
  GRADE not reported

Allopurinol mouthrinse vs placebo/no treatment

Allopurinol mouthrinse showed no clear difference in oral mucositis (any severity) compared with placebo/no treatment; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.77 [0.5, 1.19]
  4 studies
  GRADE not reported

Intestinal trefoil factor vs placebo

Intestinal trefoil factor led to lower oral mucositis (any severity) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.52 [0.35, 0.79]
  1 study · 99 participants
  GRADE not reported

Povidone vs Water

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  no estimate extracted
  2 studies
  GRADE not reported

Zinc sulphate vs placebo

Zinc sulphate showed no clear difference in oral mucositis (any severity) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.88 [0.69, 1.11]
  1 study · 27 participants
  GRADE not reported

Amifostine vs placebo/no treatment

Amifostine probably leads to lower oral mucositis (any severity) compared with placebo/no treatment (moderate certainty).

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.95 [0.91, 0.99]
  3 studies · 430 participants
  Moderate

Benzydamine vs placebo

Benzydamine led to lower oral mucositis (any severity) compared with placebo; GRADE not reported.

• Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes

  Median 28 days
  RR 0.67 [0.47, 0.97]
  1 study · 36 participants
  GRADE not reported