Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

473 questions · 480 findings · 60 reviews · Headline outcomes only

No studies found 100 · 20.8%GRADE not reported 3 · 0.6%Very low 104 · 21.7%Low 129 · 26.9%Moderate 106 · 22.1%High 38 · 7.9%

Serlopitant 0.25 mg vs placebo

Sleep disturbances: number of participants with insomnia · chronic pruritus of unknown origin

It is very uncertain whether serlopitant 0.25 mg changes sleep disturbances: number of participants with insomnia compared with placebo (very low certainty).

1 finding from 1 review

Serlopitant 5 mg vs placebo

Sleep disturbances: number of participants with insomnia · chronic pruritus of unknown origin

It is very uncertain whether serlopitant 5 mg changes sleep disturbances: number of participants with insomnia compared with placebo (very low certainty).

1 finding from 1 review