Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,841 questions · 1,893 findings · 109 reviews · Headline outcomes only

No studies found 546 · 28.8%GRADE not reported 117 · 6.2%Very low 613 · 32.4%Low 473 · 25%Moderate 118 · 6.2%High 26 · 1.4%

NSAIDs vs placebo

Patient Global Impression of Change much or very much improved · adults with sickle cell disease in a vaso‐occlusive crisis

It is very uncertain whether non‐steroidal anti‐inflammatory drugs (NSAID) changes PGIC much or very much improved ( compared with placebo (very low certainty).

1 finding from 1 review