Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,679 questions · 1,720 findings · 335 reviews · Headline outcomes only

No studies found 192 · 11.2%GRADE not reported 75 · 4.4%Very low 526 · 30.6%Low 504 · 29.3%Moderate 305 · 17.7%High 118 · 6.9%

Vitrectomy vs vitreous tap biopsy and antibiotic injection

Improvement in visual acuity at 3 months' · people with endophthalmitis following intraocular surgery

It is very uncertain whether vitrectomy changes proportion of people with a visual acuity improvement of 10 letters… compared with vitreous tap biopsy and antibiotic injection (very low certainty).

1 finding from 1 review

Vitrectomy vs vitreous tap biopsy and antibiotic injection

Additional surgical procedure, including vitrectomy and cataract surgery. · people with endophthalmitis following intraocular surgery

Vitrectomy showed no clear difference in additional surgical procedure, including vitrectomy and cataract… compared with vitreous tap biopsy and antibiotic injection (low certainty).

1 finding from 1 review

Prophylactic CPAP vs mechanical ventilation

Combined outcome of death and bronchopulmonary dysplasia defined as death at any time and oxygen dependency at 36 weeks' postmenstrual age · preterm infants

Prophylactic CPAP probably leads to lower combined outcome of death and bronchopulmonary dysplasia defined as… compared with mechanical ventilation (moderate certainty).

1 finding from 1 review

Prophylactic CPAP vs mechanical ventilation

Failed treatment defined as the need for mechanical ventilation · preterm infants

Prophylactic CPAP probably leads to lower failed treatment defined as the need for mechanical ventilation compared with mechanical ventilation (moderate certainty).

1 finding from 1 review

Prophylactic CPAP vs mechanical ventilation

Bronchopulmonary dysplasia at 36 weeks defined as oxygen dependency at 36 weeks postmenstrual age · preterm infants

Prophylactic CPAP probably leads to lower bronchopulmonary dysplasia at 36 weeks defined as oxygen dependency… compared with mechanical ventilation (moderate certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis: UFH vs no treatment

Symptomatic thromboembolic events ( · women with varicose veins before birth, having a caesarean (elective or emergency) or vaginal birth

It is very uncertain whether peripartum/postnatal prophylaxis: UFH changes symptomatic thromboembolic events ( compared with no treatment (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis: UFH vs no treatment

Symptomatic PE · women with varicose veins before birth, having a caesarean (elective or emergency) or vaginal birth

It is very uncertain whether peripartum/postnatal prophylaxis: UFH changes symptomatic PE ( compared with no treatment (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis: UFH vs no treatment

Symptomatic DVT · women with varicose veins before birth, having a caesarean (elective or emergency) or vaginal birth

It is very uncertain whether peripartum/postnatal prophylaxis: UFH changes symptomatic DVT ( compared with no treatment (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Symptomatic thromboembolic events ( · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) changes symptomatic thromboembolic events (timing of assessment unclear,… compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Symptomatic PE · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) changes symptomatic PE (timing of assessment unclear, within 6 weeks… compared with no treatment/placebo (very low certainty).

1 finding from 1 review