Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,938 questions · 1,994 findings · 246 reviews · Headline outcomes only

No studies found 490 · 24.6%GRADE not reported 71 · 3.6%Very low 669 · 33.6%Low 446 · 22.4%Moderate 264 · 13.2%High 54 · 2.7%

Injectional collagenase vs placebo

Patient‐reported ability to have intercourse · men with Peyronie's disease (diagnosis of disease: at least 12 months, penile curvature: at least 30 degrees)

The review found no eligible studies for this question.

2 findings from 1 review

Injectional collagenase vs placebo

Treatment‐related adverse effects · men with Peyronie's disease (diagnosis of disease: at least 12 months, penile curvature: at least 30 degrees)

The review found no eligible studies for this question.

2 findings from 1 review

Injectional collagenase vs placebo

Treatment discontinuation · men with Peyronie's disease (diagnosis of disease: at least 12 months, penile curvature: at least 30 degrees)

The review found no eligible studies for this question.

2 findings from 1 review

Injectional verapamil vs saline (short‐term)

Patient‐reported ability to have intercourse · men with Peyronie's disease (palpable plaque or pain)

It is very uncertain whether injectional verapamil changes patient‐reported ability to have intercourse compared with saline (short‐term) (very low certainty).

1 finding from 1 review

Potassium paraaminobenzoate vs placebo

Treatment‐related adverse effects · men with acute (maximum of 12 months) Peyronie's disease with no prior treatment and no evidence of calcified plaques (pain during…

It is very uncertain whether potassium paraaminobenzoate changes treatment‐related adverse effects compared with placebo (very low certainty).

1 finding from 1 review