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What do systematic reviews say?

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Evidence found and GRADE certainty

2,038 questions · 2,118 findings · 339 reviews

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No studies found 323 · 15.3%GRADE not reported 166 · 7.8%Very low 552 · 26.1%Low 592 · 28%Moderate 340 · 16.1%High 145 · 6.8%

Intervention not reported

30‐Day amputation‐free survival · patients with less than 42 days' lower limb ischaemia
1 finding from 1 review

Intervention not reported

30‐Day mortality · patients with less than 42 days' lower limb ischaemia
1 finding from 1 review

Intervention not reported

Vessel patency ( · patients with less than 42 days' lower limb ischaemia

It is very uncertain whether the intervention changes vessel patency ( (very low certainty).

1 finding from 1 review

Intervention not reported

Major bleeding ( · patients with less than 42 days' lower limb ischaemia

It is very uncertain whether the intervention changes major bleeding ( (very low certainty).

1 finding from 1 review

Higher threshold (500 mL per six hours or greater) vs lower threshold (less than 500 mL per six hours) at time of aspiration

Mortality (at the end of · adults receiving EN via nasogastric or gastrostomy tube

It is very uncertain whether higher threshold (500 mL per six hours or greater) changes mortality (at the end of compared with lower threshold (less than 500 mL per six hours) at time of aspiration (very low certainty).

1 finding from 1 review

Higher threshold (500 mL per six hours or greater) vs lower threshold (less than 500 mL per six hours) at time of aspiration

Pneumonia · adults receiving EN via nasogastric or gastrostomy tube

It is very uncertain whether higher threshold (500 mL per six hours or greater) changes pneumonia (until discontinued or up to 28 days) compared with lower threshold (less than 500 mL per six hours) at time of aspiration (very low certainty).

1 finding from 1 review