Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

3,601 questions in 252 reviews · Pregnancy and Childbirth

current versions
No studies 726 · 20.2%Ungraded 421 · 11.7%Very low 828 · 23%Low 993 · 27.6%Moderate 486 · 13.5%High 147 · 4.1%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Needle aspiration vs incision and drainage
Continuation of breastfeeding · Breastfeeding women with breast abscesses
Treatments for breast abscesses in breastfeeding women (2015) · Cochrane
no estimate extracted2 participantsUngraded
Needle aspiration vs incision and drainage
Treatment failure · Breastfeeding women with breast abscesses
Treatments for breast abscesses in breastfeeding women (2015) · Cochrane
RR 16.12 [2.21, 117.73]2 studies · 115 participantsLow
Bishop score vs transvaginal ultrasound
Vaginal birth · women with singleton cephalic fetuses undergoing assessment for pre‐induction cervical ripening.
Methods for assessing pre‐induction cervical ripening (2015) · Cochrane
RR 1.05 [0.92, 1.2]2 studies · 234 participantsModerate
Bishop score vs transvaginal ultrasound
Caesarean delivery · women with singleton cephalic fetuses undergoing assessment for pre‐induction cervical ripening.
Methods for assessing pre‐induction cervical ripening (2015) · Cochrane
RR 0.82 [0.5, 1.35]2 studies · 234 participantsModerate
Bishop score vs transvaginal ultrasound
Neonatal admission to NICU · women with singleton cephalic fetuses undergoing assessment for pre‐induction cervical ripening.
Methods for assessing pre‐induction cervical ripening (2015) · Cochrane
RR 1.67 [0.41, 6.83]2 studies · 234 participantsModerate
Bishop score vs transvaginal ultrasound
Need of misoprostol for cervical ripening · women with singleton cephalic fetuses undergoing assessment for pre‐induction cervical ripening.
Methods for assessing pre‐induction cervical ripening (2015) · Cochrane
RR 0.53 [0.42, 0.67]2 studies · 234 participantsModerate
Bishop score vs transvaginal ultrasound
Meconium staining of amniotic fluid · women with singleton cephalic fetuses undergoing assessment for pre‐induction cervical ripening.
Methods for assessing pre‐induction cervical ripening (2015) · Cochrane
RR 0.75 [0.37, 1.51]2 studies · 234 participantsModerate
Bishop score vs transvaginal ultrasound
Apgar score at 5 minutes less than 7 · women with singleton cephalic fetuses undergoing assessment for pre‐induction cervical ripening.
Methods for assessing pre‐induction cervical ripening (2015) · Cochrane
RR 0.62 [0.08, 4.99]2 studies · 234 participantsModerate
Bishop score vs transvaginal ultrasound
Fetal heart rate abnormality in labour · women with singleton cephalic fetuses undergoing assessment for pre‐induction cervical ripening.
Methods for assessing pre‐induction cervical ripening (2015) · Cochrane
RR 1 [0.21, 4.8]1 study · 154 participantsUngraded
Intravenous iron vs oral iron
Maternal mortality Clinical assessment · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
RR 2.95 [0.12, 71.96]2 studies · 374 participantsLow
Red blood cell transfusion vs non‐transfusion (Comparison 2)
Persistent anaemia symptoms Reported by the women · patients with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extracted1 study · 519 participantsVery low
Red blood cell transfusion vs non‐transfusion (Comparison 2)
Infections Clinical assessment · patients with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
RR 0.93 [0.53, 1.61]1 study · 519 participantsModerate
Red blood cell transfusion vs non‐transfusion (Comparison 2)
Erythrocyte alloantibody formation Laboratory assessment · patients with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
RR 3.03 [0.12, 74.15]1 study · 519 participantsVery low
Red blood cell transfusion vs non‐transfusion (Comparison 2)
Thromboembolic events Assessment method not described · patients with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
RR 1.01 [0.14, 7.13]1 study · 519 participantsLow
Red blood cell transfusion vs non‐transfusion (Comparison 2)
Transfusion reactions Clinical assessment · patients with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
RR 7.08 [0.37, 136.41]1 study · 519 participantsVery low
Oral iron vs placebo (Comparison 3)
Maternal mortality ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Oral iron vs placebo (Comparison 3)
Fatigue ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Oral iron vs placebo (Comparison 3)
Persistent anaemia symptoms Reported by the women · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extracted1 study · 1 participantsUngraded
Oral iron vs placebo (Comparison 3)
All gastrointestinal symptoms Reported by the patients · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
RR 1 [0.36, 2.79]1 study · 68 participantsVery low
Oral iron vs placebo (Comparison 3)
Constipation ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Intravenous iron vs oral iron
Fatigue at 14, 28, and 42 days Fatigue Linear Analog Scale Assessment. Scale from: 0 to 100. · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extracted1 study · 361 participantsVery low
Intravenous iron with oral iron vs oral iron (Comparison 6)
Maternal mortality · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Intravenous iron with oral iron vs oral iron (Comparison 6)
Fatigue ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Intravenous iron with oral iron vs oral iron (Comparison 6)
Persistent anaemia symptoms ‐ 1 week Visual Analogue Scale ≥ 7 · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
RR 1.75 [0.56, 5.46]1 study · 72 participantsVery low
Intravenous iron with oral iron vs oral iron (Comparison 6)
Persistent anaemia symptoms ‐ 2 weeks Visual Analogue Scale ≥ 7 · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
RR 0.6 [0.15, 2.33]1 study · 72 participantsVery low
Intravenous iron with oral iron vs oral iron (Comparison 6)
Persistent anaemia symptoms ‐ 6 weeks Visual Analogue Scale ≥ 7 · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
RR 3 [0.33, 27.5]1 study · 72 participantsVery low
Intravenous iron with oral iron vs oral iron (Comparison 6)
Infections ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Intravenous iron with oral iron vs oral iron (Comparison 6)
Anaphylaxis or evidence of hypersensitivity Clinical assessment · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extracted0 studies · 1 participantsLow
Erythropoietin (regardless of rout) with intravenous iron vs intravenous iron (Comparison 7)
Maternal mortality · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Erythropoietin (regardless of rout) with intravenous iron vs intravenous iron (Comparison 7)
Fatigue ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Erythropoietin (regardless of rout) with intravenous iron vs intravenous iron (Comparison 7)
Thromboembolic events ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Intravenous iron vs oral iron
Persistent anaemia symptoms ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Erythropoietin (regardless of rout) with intravenous iron vs intravenous iron (Comparison 7)
Persistent anaemia symptoms ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Subcutaneous EPO 10,000 U of doses with intravenous iron vs intravenous iron (Comparison 8)
Maternal mortality ‐ not reported · patients with women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Subcutaneous EPO 10,000 U of doses with intravenous iron vs intravenous iron (Comparison 8)
Fatigue ‐ not reported · patients with women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Subcutaneous EPO 10,000 U of doses with intravenous iron vs intravenous iron (Comparison 8)
Persistent anaemia symptoms ‐ not reported · patients with women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Subcutaneous EPO 10,000 U of doses with intravenous iron vs intravenous iron (Comparison 8)
Thromboembolic events ‐ not reported · patients with women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Subcutaneous EPO with oral iron vs oral iron (Comparison 10)
Maternal mortality · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extracted0 studies · 40 participantsUngraded
Subcutaneous EPO with oral iron vs oral iron (Comparison 10)
Fatigue ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Subcutaneous EPO with oral iron vs oral iron (Comparison 10)
Persistent anaemia symptoms ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Subcutaneous EPO with oral iron vs oral iron (Comparison 10)
Thromboembolic events ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Subcutaneous EPO with intravenous iron and oral iron vs intravenous iron with oral iron (Comparison 12)
Maternal mortality ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Intravenous iron vs oral iron
Infections Clinical assessment · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
RR 1.7 [0.58, 5.03]3 studies · 718 participantsVery low
Subcutaneous EPO with intravenous iron and oral iron vs intravenous iron with oral iron (Comparison 12)
Fatigue ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Subcutaneous EPO with intravenous iron and oral iron vs intravenous iron with oral iron (Comparison 12)
Persistent anaemia symptoms ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Subcutaneous EPO with intravenous iron and oral iron vs intravenous iron with oral iron (Comparison 12)
Thromboembolic events ‐ not reported · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies
Intravenous iron vs oral iron
Constipation Reported by the women · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
RR 0.21 [0.11, 0.39]6 studies · 1217 participantsVery low
Intravenous iron vs oral iron
All gastrointestinal symptoms Reported by the women · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
RR 0.31 [0.2, 0.47]8 studies · 1307 participantsVery low
Intravenous iron vs oral iron
Anaphylaxis or evidence of hypersensitivity Clinical assessment · women with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
RR 2.78 [0.31, 24.92]8 studies · 1454 participantsLow
Red blood cell transfusion vs non‐transfusion (Comparison 2)
Maternal mortality ‐ not reported · patients with postpartum iron deficiency anaemia
Treatment for women with postpartum iron deficiency anaemia (2015) · Cochrane
no estimate extractedNRNo studies