Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,413 questions · 2,602 findings · 93 reviews · Oral Health

No studies found 452 · 17.4%GRADE not reported 1,582 · 60.8%Very low 392 · 15.1%Low 122 · 4.7%Moderate 53 · 2%High 1 · 0%

SPI Element sand-blasted acid-etched standard implants vs SPI Element SurfLink-modified implants

Marginal bone level change · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

SPI Element sand-blasted acid-etched standard implants showed no clear difference in marginal bone level change compared with SPI Element SurfLink-modified implants; GRADE not reported.

1 finding from 1 review

Maxillary sinus lift (augmentation) with long implants vs Short implants (5 to 8.5 mm) without sinus augmentation

Complications (at treated sites) · Patients with missing teeth and an atrophic posterior maxilla, with residual bone height between 4 and 9 mm below the maxillary sinus

Maxillary sinus lift (augmentation) with long implants may leads to higher complications (at treated sites) compared with short implants (5 to 8.5 mm) without sinus augmentation (low certainty).

1 finding from 1 review

ITI SLA titanium screws vs Southern blasted/etched titanium screws

Marginal bone level change · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

ITI SLA titanium screws showed no clear difference in marginal bone level change compared with southern blasted/etched titanium screws; GRADE not reported.

1 finding from 1 review

An intervention delivered at one time point vs The same intervention delivered at a different time point

Outcome not reported · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve

The review found no eligible studies for this question.

1 finding from 1 review

NobelActive external connection implants vs NobelReplace implants

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelActive external connection implants showed no clear difference in implant failure compared with nobelReplace implants; GRADE not reported.

1 finding from 1 review

Branemark Mark IV TiUnite titanium screws vs Southern regular titanium screws

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

Branemark Mark IV TiUnite titanium screws showed no clear difference in implant failure compared with southern regular titanium screws; GRADE not reported.

1 finding from 1 review

One-stage crestal-approach sinus lift with autogenous bone and 8 mm implants vs Lateral-window sinus lift with 50% autogenous bone/50% Bio-Oss and implants at least 10 mm long

Implant failure · Patients with 3 to 6 mm of residual bone height at the sinus floor

One-stage crestal-approach sinus lift with autogenous bone and 8 mm… showed no clear difference in implant failure compared with lateral-window sinus lift with 50% autogenous bone/50% Bio-Oss and…; GRADE not reported.

1 finding from 1 review

Sucralfate suspension (topical) vs Placebo suspension

Time to complete healing · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Sucralfate suspension (topical) showed no clear difference in healing time compared with placebo suspension; GRADE not reported.

1 finding from 1 review

Sucralfate suspension (topical) vs Placebo suspension

Number of episodes · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Sucralfate suspension (topical) showed no clear difference in number of episodes compared with placebo suspension; GRADE not reported.

1 finding from 1 review

Maxillary sinus lift (augmentation) with long implants vs Short implants (5 to 8.5 mm) without sinus augmentation

Augmentation procedure failure · Patients with missing teeth and an atrophic posterior maxilla, with residual bone height between 4 and 9 mm below the maxillary sinus
1 finding from 1 review

Sucralfate suspension (topical) vs Placebo suspension

Pain (0-3 scale) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Sucralfate suspension (topical) showed no clear difference in pain (0-3 scale) compared with placebo suspension; GRADE not reported.

1 finding from 1 review

Astra TiO2-blasted titanium screws vs Branemark turned titanium screws

Marginal bone level change · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

Astra TiO2-blasted titanium screws showed no clear difference in marginal bone level change compared with branemark turned titanium screws; GRADE not reported.

1 finding from 1 review

MegaGen EZ Plus blasted standard implants vs MegaGen EZ Plus calcium-incorporated (Xpeed) implants

Marginal bone level change · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

MegaGen EZ Plus blasted standard implants showed no clear difference in marginal bone level change compared with megaGen EZ Plus calcium-incorporated (Xpeed) implants; GRADE not reported.

1 finding from 1 review

Maxillary sinus lift (augmentation) with long implants vs Short implants (5 to 8.5 mm) without sinus augmentation

Implant failure · Patients with missing teeth and an atrophic posterior maxilla, with residual bone height between 4 and 9 mm below the maxillary sinus

Maxillary sinus lift (augmentation) with long implants showed no clear difference in implant failure compared with short implants (5 to 8.5 mm) without sinus augmentation (moderate certainty).

1 finding from 1 review

Aciclovir (systemic; 800 mg 5x/day for 1 week then 400 mg 2x/day for 11 weeks) vs placebo

Episode frequency associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Davies 1988 (aciclovir vs placebo, 36 patients, cross-over; high risk of reporting bias; concomitant treatments): data were not presented in a usable format; authors reported no statistically significant difference in…
    1 study · 36 participants
    GRADE not reported

Interferon-alpha (topical lozenges) vs placebo

Total number of oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Interferon-alpha (topical; hydrogel or lozenges) showed no clear difference in total number of oral ulcers compared with placebo; GRADE not reported.

1 finding from 1 review

One-stage crestal-approach sinus lift with autogenous bone and 8 mm implants vs Lateral-window sinus lift with 50% autogenous bone/50% Bio-Oss and implants at least 10 mm long

Partial graft loss · Patients with 3 to 6 mm of residual bone height at the sinus floor

One-stage crestal-approach sinus lift with autogenous bone and 8 mm… showed no clear difference in partial graft loss compared with lateral-window sinus lift with 50% autogenous bone/50% Bio-Oss and…; GRADE not reported.

1 finding from 1 review

One-stage lateral sinus lift with monocortical autogenous bone blocks (iliac crest) vs Two-stage lateral sinus lift with autogenous particulate bone (iliac crest)

Implant failure · Patients with 2 to 7 mm of residual alveolar bone height in the edentulous maxillary sinus floor

One-stage lateral sinus lift with monocortical autogenous bone… showed no clear difference in implant failure compared with two-stage lateral sinus lift with autogenous particulate bone (iliac…; GRADE not reported.

1 finding from 1 review