Patient behaviours and actions · Adults (25‐60 years)
1 finding from 1 review
Health service outcomes · Adults (25‐60 years)
1 finding from 1 review
Health professional outcomes · Adults (25‐60 years)
1 finding from 1 review
Harms · Adults (25‐60 years)
1 finding from 1 review
IRLS · patients with restless legs syndrome according to IRLSSG, 18 years or older
1 finding from 1 review
Adverse effects (drop‐outs due to adverse effects4) · patients with restless legs syndrome
Summary of findings: dopamine agonists probably leads to higher number of drop outs due to adverse events compared with levodopa (moderate certainty).
1 finding from 1 review
Clinical Global Impressions ‐ Improvement of condition (CGI‐I) Rating of 1 = very much improved to 7 = very much worse · patients with restless legs syndrome
Summary of findings: dopamine agonists showed no clear difference in clinical Global Impressions ‐ Improvement of condition (CGI‐I)… compared with levodopa (moderate certainty).
1 finding from 1 review
Quality of sleep · patients with restless legs syndrome
1 finding from 1 review
QoL · patients with restless legs syndrome
1 finding from 1 review
Number of participants reporting an adverse event · patients with restless legs syndrome
Summary of findings: dopamine agonists showed no clear difference in number of patients experiencing adverse events compared with levodopa (moderate certainty).
1 finding from 1 review
Periodic limb movements in sleep (PLMS Index) PLMS per hour of sleep (8 trials) or time in bed (7 trials) · patients with restless legs syndrome according to IRLSSG, 18 years or older
1 finding from 1 review
Sleep efficiency · patients with restless legs syndrome according to IRLSSG, 18 years or older
1 finding from 1 review
Withdrawals due to adverse events · patients with restless legs syndrome according to IRLSSG, 18 years or older
Summary of findings: dopamine agonists leads to higher number of dropouts due to adverse events compared with placebo (high certainty).
1 finding from 1 review
Clinical Global Impressions ‐ Improvement of condition (CGI‐I) Rating of 1 = very much improved to 7 = very much worse · patients with restless legs syndrome according to IRLSSG, 18 years or older
Summary of findings: dopamine agonists leads to higher clinical Global Impressions ‐ Improvement of condition (CGI‐I)… compared with placebo (high certainty).
1 finding from 1 review
Subjective sleep quality or quantity · patients with restless legs syndrome according to IRLSSG, 18 years or older
1 finding from 1 review
QoL · patients with restless legs syndrome according to IRLSSG, 18 years or older
1 finding from 1 review
IRLS · patients with restless legs syndrome
1 finding from 1 review
Periodic limb movements per hour of time in bed · patients with restless legs syndrome
1 finding from 1 review
FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis
1 finding from 1 review
Time to next pulmonary exacerbation · adults and children with cystic fibrosis
1 finding from 1 review