Findings

What do systematic reviews say?

1,835 questions · 1,886 findings · 74 reviews · Skin

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No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Lesion count · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 207 participants
Moderate

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Time needed until improvement · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 207 participants
High

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Participant‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Proportion of participants with adverse event · Participants with rosacea

Minocycline 45 mg showed no clear difference in proportion of participants with adverse event compared with minocycline 45 mg + azelaic acid gel (low certainty).

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
RR 0.69 [0.39, 1.22]
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Physician‐assessed improvement in rosacea severity · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Assessment of erythema or telangiectasia · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Azelaic acid vs placebo

Proportion of participants with adverse event · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1245 participants
High

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Lesion count · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Time needed until improvement · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Low

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical metronidazole vs oral (oxy)tetracycline

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical metronidazole vs oral (oxy)tetracycline

Participant‐assessed improvement in rosacea severity · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 182 participants
Moderate

Topical metronidazole vs oral (oxy)tetracycline

Proportion of participants with adverse event · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 258 participants
Moderate

Topical metronidazole vs oral (oxy)tetracycline

Physician‐assessed improvement in rosacea severity · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 81 participants
Moderate

Topical metronidazole vs oral (oxy)tetracycline

Assessment of erythema or telangiectasia · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 258 participants
Low

Topical metronidazole vs oral (oxy)tetracycline

Lesion count · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 258 participants
Moderate

Topical metronidazole vs oral (oxy)tetracycline

Time needed until improvement ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Azelaic acid vs placebo

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Azelaic acid leads to higher physician‐assessed improvement in rosacea severity compared with placebo (high certainty).

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
RR 1.32 [1.18, 1.47]
4 studies · 1179 participants
High