Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,262 questions · 2,405 findings · 248 reviews · Headline outcomes only

No studies found 507 · 21.1%GRADE not reported 93 · 3.9%Very low 657 · 27.3%Low 708 · 29.4%Moderate 387 · 16.1%High 53 · 2.2%

Multi‐domain interventions vs placebo or usual care

Cognitive decline · Older people living in the community
3 findings from 1 review

Casirivimab/imdevimab vs usual care

Clinical progression: IMV or death (≥ 7 WHO scale) · hospitalised individuals with COVID‐19 (moderate to severe disease)

Casirivimab/imdevimab showed no clear difference in clinical progression: need for IMV or death (WHO ≥ 7) compared with usual care alone (moderate certainty).

1 finding from 1 review