Findings

What do systematic reviews say?

1,822 questions · 1,891 findings · 321 reviews · Headline outcomes only

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No studies found 279 · 14.8%GRADE not reported 46 · 2.4%Very low 524 · 27.7%Low 571 · 30.2%Moderate 330 · 17.5%High 141 · 7.5%

Higher vs lower PUFA

All allergic disease ‐ Infancy (incidence) · infants

It is very uncertain whether higher changes all allergic disease ‐ infant incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.96 [0.73, 1.26]
1 study · 323 participants
Very low

Higher vs lower PUFA

All allergic disease ‐ childhood prevalence · infants

It is very uncertain whether higher changes all allergic disease ‐ childhood prevalence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.98 [0.81, 1.19]
2 studies · 633 participants
Very low

Higher vs lower PUFA

Asthma ‐ childhood prevalence · infants

It is very uncertain whether higher changes asthma ‐ childhood prevalence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 1.12 [0.82, 1.53]
2 studies · 635 participants
Very low

Higher vs lower PUFA

Dermatitis/eczema ‐ childhood prevalence · infants

It is very uncertain whether higher changes dermatitis/eczema ‐ childhood prevalence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.81 [0.59, 1.09]
2 studies · 635 participants
Very low

Higher vs lower PUFA

Allergic rhinitis ‐ childhood prevalence · infants

It is very uncertain whether higher changes allergic rhinitis ‐ childhood prevalence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 1.02 [0.83, 1.25]
2 studies · 635 participants
Very low

Higher vs lower PUFA

Food allergy ‐ childhood prevalence · infants

It is very uncertain whether higher changes food allergy ‐ childhood prevalence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.27 [0.06, 1.19]
1 study · 119 participants
Very low

Higher vs lower PUFA

Asthma ‐ Infancy (incidence) · infants

Higher showed no clear difference in asthma ‐ infant incidence compared with lower PUFA intake (low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 1.04 [0.8, 1.35]
3 studies · 1162 participants
Low

Higher vs lower PUFA

Eczema ‐ Infancy (incidence) · infants

It is very uncertain whether higher changes dermatitis/eczema ‐ infant incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.93 [0.82, 1.06]
7 studies · 1906 participants
Very low

Higher vs lower PUFA

Allergic rhinitis ‐ infant incidence · infants

It is very uncertain whether higher changes allergic rhinitis ‐ infant incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.47 [0.23, 0.96]
2 studies · 594 participants
Very low

Higher vs lower PUFA

Food allergy ‐ Infancy (incidence) · infants

It is very uncertain whether higher changes food allergy ‐ infant incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.81 [0.56, 1.19]
3 studies · 915 participants
Very low

Higher vs lower PUFA

All allergic disease ‐ childhood (incidence) · infants

It is very uncertain whether higher changes all allergic disease ‐ childhood incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.69 [0.47, 1.02]
2 studies · 154 participants
Very low

Higher vs lower PUFA

Asthma ‐ childhood (incidence) · infants

It is very uncertain whether higher changes asthma ‐ childhood incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.45 [0.2, 1.02]
1 study · 89 participants
Very low

Higher vs lower PUFA

Eczema ‐ childhood (incidence) · infants

It is very uncertain whether higher changes dermatitis/eczema ‐ childhood incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 0.65 [0.34, 1.24]
2 studies · 154 participants
Very low

Higher vs lower PUFA

Food allergy ‐ childhood (incidence) · infants

It is very uncertain whether higher changes food allergy ‐ childhood incidence compared with lower PUFA intake (very low certainty).

1 finding from 1 review

Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy 2016 · Cochrane Headline outcomes only
RR 2.27 [0.25, 20.68]
1 study · 65 participants
Very low

Adults: higher dose/longer course vs lower dose/shorter course

Re‐admission during · Adults with acute asthma

Adults: higher dose/longer course showed no clear difference in re‐admission in compared with lower dose/shorter course (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 1.35 [0.38, 4.79]
4 studies · 142 participants
Low

Children: higher dose/longer course vs lower dose/shorter course

Re‐admission during · children with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 98 participants
Very low

Children: higher dose/longer course vs lower dose/shorter course

Asthma symptoms · children with acute asthma

Children: higher dose/longer course showed no clear difference in asthma symptoms Symptom free by 7 days compared with lower dose/shorter course (moderate certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 1.22 [0.67, 2.19]
1 study · 201 participants
Moderate

Children: higher dose/longer course vs lower dose/shorter course

Serious adverse events · children with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 201 participants
GRADE not reported

Children: higher dose/longer course vs lower dose/shorter course

Exacerbations · children with acute asthma

Children: higher dose/longer course showed no clear difference in new exacerbation during compared with lower dose/shorter course (low certainty).

2 findings from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 1.38 [0.25, 7.47]
2 studies · 231 participants
Low
Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 2.17 [0.67, 7.01]
1 study · 100 participants
Very low

Children: higher dose/longer course vs lower dose/shorter course

FEV1 % predicted · children with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
GRADE not reported