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What do systematic reviews say?

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Evidence found and GRADE certainty

1,655 questions · 1,751 findings · 147 reviews · Pain, Palliative and Supportive Care

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No studies found 361 · 20.6%GRADE not reported 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%

Intervention not reported

Moderate benefit: at least 30% reduction in pain, or PGIC much or very much improved · Adults with chronic neuropathic pain
1 finding from 1 review

Intervention not reported

Substantial benefit: at least 50% reduction in pain, or PGIC much improved · Adults with chronic neuropathic pain

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Lack of efficacy withdrawal in randomised double‐blind phase · Adults with chronic neuropathic pain
1 finding from 1 review

Intervention not reported

Adverse event withdrawal in randomised double‐blind phase · Adults with chronic neuropathic pain
1 finding from 1 review

Intervention not reported

Serious adverse events · Adults with chronic neuropathic pain
1 finding from 1 review

Intervention not reported

Deaths · Adults with chronic neuropathic pain
1 finding from 1 review

Pregabalin vs placebo

Maintenance of initial therapeutic response of at least 30% pain intensity reduction over baseline and continued treatment at 13 or 26 weeks (equivalent to 'moderate benefit') · adults with fibromyalgia enrolled in EERW studies
1 finding from 1 review